| Monarch Ortholog Phenotypes
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Human (32 sources):
Ankle flexion contracture,
Areflexia,
Arthrogryposis multiplex congenita,
Camptodactyly,
Decreased fetal movement,
Dental crowding,
Distal arthrogryposis,
EMG abnormality,
Elbow flexion contracture,
Esotropia,
Fetal akinesia sequence,
Flexion contracture,
Generalized hypotonia,
High palate,
Hip contracture,
Hypotonia,
Internally rotated shoulders,
Knee flexion contracture,
Limitation of joint mobility,
Micrognathia,
Narrow forehead,
Poor head control,
Protruding ear,
Ptosis,
Pulmonary hypoplasia,
Reduced tendon reflexes,
Respiratory distress,
Retrognathia,
Scapular winging,
Seizure,
Strabismus,
Talipes equinovarus
[+]
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Mouse (24 sources):
abnormal PNS glial cell morphology,
abnormal Schwann cell morphology,
abnormal anxiety-related response,
abnormal axon morphology,
abnormal forelimb morphology,
abnormal glial cell morphology,
abnormal glial cell physiology,
abnormal hindlimb morphology,
abnormal limb morphology,
abnormal locomotor activation,
abnormal locomotor behavior,
abnormal maternal nurturing,
abnormal myelin sheath morphology,
abnormal sciatic nerve morphology,
abnormal sexual interaction,
decreased body size,
decreased diameter of radius,
decreased diameter of ulna,
decreased thigmotaxis,
impaired righting response,
muscle phenotype,
neonatal lethality, incomplete penetrance,
postnatal lethality, incomplete penetrance,
preweaning lethality, complete penetrance
[+]
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View all ortholog results at Monarch
|
Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.