| Monarch Ortholog Phenotypes
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Human (7 sources):
Basal cell carcinoma,
Milia,
Neoplasm,
Neoplasm of the skin,
Papule,
Subcutaneous nodule,
Telangiectasia of the skin
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Mouse (44 sources):
abnormal Peyer's patch germinal center morphology,
abnormal class switch recombination,
abnormal colon morphology,
abnormal grip strength,
abnormal humoral immune response,
abnormal intestinal epithelium morphology,
abnormal keratinocyte proliferation,
abnormal locomotor activation,
abnormal lung development,
abnormal lung interstitium morphology,
abnormal mature B cell morphology,
abnormal spleen marginal zone morphology,
decreased B-1 B cell number,
decreased CD4-positive, alpha beta T cell number,
decreased IgG3 level,
decreased birth body size,
decreased immature B cell number,
decreased susceptibility to bacterial infection,
decreased susceptibility to bacterial infection induced morbidity/mortality,
enlarged Peyer's patches,
enlarged lymph nodes,
epidermal hyperplasia,
hunched posture,
immune system phenotype,
impaired fibroblast cell migration,
increased IgG1 level,
increased IgG2a level,
increased IgG2b level,
increased cell proliferation,
increased double-positive T cell number,
increased follicular B cell number,
increased incidence of tumors by chemical induction,
increased keratinocyte proliferation,
increased marginal zone B cell number,
increased pro-B cell number,
increased skin papilloma incidence,
increased susceptibility to induced colitis,
kinked tail,
neonatal lethality, complete penetrance,
no abnormal phenotype detected,
premature death,
short tail,
small lung,
thick lung-associated mesenchyme
[+]
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View all ortholog results at Monarch
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Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.