| Monarch Ortholog Phenotypes
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Human (1 source):
Cognitive impairment
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Mouse (34 sources):
abnormal T cell differentiation,
abnormal cytokine level,
abnormal intestinal goblet cell morphology,
abnormal intestinal mucosa morphology,
abnormal jejunum crypts of Lieberkuhn morphology,
abnormal sleep behavior,
abnormal small intestine crypts of Lieberkuhn morphology,
abnormal thymus cell ratio,
abnormal thymus cortex morphology,
abnormal thymus corticomedullary boundary morphology,
decreased CD4-positive, alpha beta T cell number,
decreased Paneth cell number,
decreased body size,
decreased double-positive T cell number,
decreased locomotor activity,
decreased thymocyte number,
digestive/alimentary phenotype,
enlarged lymph nodes,
enlarged thymus medulla,
growth/size/body region phenotype,
hunched posture,
increased CD8-positive, alpha-beta T cell number,
increased T cell derived lymphoma incidence,
increased T cell proliferation,
increased effector memory CD4-positive, alpha-beta T cell number,
increased effector memory CD8-positive, alpha-beta T cell number,
increased intestinal adenoma incidence,
increased neutrophil cell number,
muscle phenotype,
no abnormal phenotype detected,
premature death,
ruffled hair,
shortened RR interval,
shortened ST segment
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View all ortholog results at Monarch
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Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.