tuba1a Phenotypes

Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.

Phenotypes

Gene Literature (8)

Nucleotides (119)

Interactants (151)

XB-GENEPAGE-22063821

Gene Symbol: tuba1a Gene Name: tubulin alpha 1a

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Computed annotations: tuba1a assayed (3 sources)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (18 sources): Agenesis of corpus callosum, Agyria, Ataxia, Cerebellar vermis hypoplasia, Generalized hypotonia, Gray matter heterotopia, Hypoplasia of the brainstem, Hypoplasia of the corpus callosum, Hypotonia, Intellectual disability, severe, Lissencephaly, Microcephaly, Motor delay, Pachygyria, Polymicrogyria, Seizure, Spastic tetraplegia, Ventriculomegaly [+]
Mouse (30 sources): abnormal Ammon gyrus morphology, abnormal auditory cortex morphology, abnormal basal ganglion morphology, abnormal cerebral cortex morphology, abnormal cerebral cortex pyramidal cell morphology, abnormal cortical intermediate zone morphology, abnormal cortical plate morphology, abnormal cortical ventricular zone morphology, abnormal dendrite morphology, abnormal dentate gyrus morphology, abnormal hippocampal mossy fiber morphology, abnormal hippocampus pyramidal cell layer, abnormal nest building behavior, abnormal neuron physiology, abnormal neuronal precursor cell number, abnormal response to novel object, abnormal somatosensory cortex morphology, abnormal spatial working memory, abnormal spine curvature, abnormal telencephalon development, abnormal third ventricle morphology, abnormal visual cortex morphology, decreased anxiety-related response, decreased hippocampus pyramidal cell number, decreased neuronal precursor proliferation, enlarged lateral ventricles, enlarged third ventricle, increased neuron apoptosis, increased neuronal precursor proliferation, preweaning lethality, complete penetrance [+]
View all ortholog results at Monarch