zeb2 Phenotypes

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Phenotypes

Gene Literature (30)

Nucleotides (206)

Interactants (506)

XB-GENEPAGE-479557

Gene Symbol: zeb2 Gene Name: zinc finger E-box binding homeobox 2

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: zeb2 assayed (5 sources)
Computed annotations: zeb2 assayed (26 sources)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (95 sources): Abdominal distention, Abnormal cardiovascular system morphology, Abnormal corpus callosum morphology, Abnormal eyebrow morphology, Abnormal heart morphology, Abnormal hippocampus morphology, Abnormality of enteric ganglion morphology, Abnormality of the genital system, Abnormality of the kidney, Abnormality of the orbital region, Absent speech, Aganglionic megacolon, Agenesis of corpus callosum, Aplasia/Hypoplasia of the cerebellum, Aplasia/Hypoplasia of the cerebral white matter, Aplasia/Hypoplasia of the corpus callosum, Atrial septal defect, Bifid scrotum, Broad columella, Broad eyebrow, Broad hallux phalanx, Camptodactyly of finger, Cataract, Cerebral cortical atrophy, Chorioretinal coloboma, Cleft palate, Cleft upper lip, Constipation, Cryptorchidism, Cupped ear, Deep plantar creases, Deeply set eye, Delayed eruption of teeth, Delayed speech and language development, Downslanted palpebral fissures, Drooling, Ectopia pupillae, Ectopic kidney, Epicanthus, Esotropia, Everted lower lip vermilion, Fine hair, Finger syndactyly, Frontal bossing, Generalized hypotonia, Generalized muscle hypertrophy, Hallux valgus, Happy demeanor, High forehead, High palate, Hydronephrosis, Hypertelorism, Hypoplasia of the corpus callosum, Hypospadias, Hypotonia, Intellectual disability, severe, Iris coloboma, Large basal ganglia, Large earlobe, Low hanging columella, Microcephaly, Microcornea, Microphthalmia, Motor delay, Myopia, Nystagmus, Open mouth, Patent ductus arteriosus, Pectus carinatum, Pectus excavatum, Pointed chin, Posteriorly rotated ears, Prominent nasal tip, Ptosis, Pulmonary artery sling, Pulmonary artery stenosis, Pulmonic stenosis, Pyloric stenosis, Recurrent otitis media, Seizure, Short stature, Strabismus, Submucous cleft hard palate, Supernumerary nipple, Tapered finger, Tetralogy of Fallot, Tooth malposition, Uplifted earlobe, Ventricular septal defect, Ventriculomegaly, Vesicoureteral reflux, Vomiting, Wide nasal bridge, Widely spaced teeth, obsolete External ear malformation [+]
Mouse (25 sources): abnormal cranial neural crest cell migration, abnormal embryo development, abnormal hair follicle bulge morphology, abnormal hair follicle melanocyte morphology, abnormal lens fiber morphology, abnormal melanoblast migration, abnormal melanoblast morphology, abnormal melanosome morphology, abnormal neural crest cell delamination, abnormal neural plate morphology, abnormal somite development, abnormal somite shape, absent first pharyngeal arch, absent hair follicle melanin granules, absent vagal neural crest cells, decreased somite size, embryonic growth arrest, embryonic lethality during organogenesis, complete penetrance, incomplete embryo turning, increased T cell acute lymphoblastic leukemia incidence, increased thymus tumor incidence, nervous system phenotype, open neural tube, premature death, reduced hair shaft melanin granule number [+]
View all ortholog results at Monarch