zic3 Phenotypes

Summary

Expression

Phenotypes

Gene Literature (100)

XB-GENEPAGE-480430

Gene Symbol: zic3 Gene Name: Zic family member 3

Anatomical Phenotypes Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.
abnormal determination of left/right symmetry (4 sources), abnormal gastrulation (4 sources), decreased length of anterior-posterior axis (3 sources), abnormal anterior-posterior axis, curved dorsal (2 sources), abnormal bending of anterior-posterior axis (2 sources), abnormal convergent extension (2 sources), abnormal incomplete closing of the blastopore (2 sources), abnormal incomplete closing of the neural tube (2 sources), abnormal left/right axis specification (2 sources), abnormal neural tube closure (2 sources), abnormal small intestine morphology (2 sources), abnormally delayed closure of blastopore (2 sources), abnormally increased area of blastopore (2 sources), abnormally localised outflow tract (2 sources), decreased size of the head (2 sources), decreased size of the tail (2 sources), abnormal development of notochord (1 source), abnormal heart looping (1 source), decreased length of notochord (1 source)

Anatomical Phenotypes

Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.

abnormal determination of left/right symmetry (4 sources), abnormal gastrulation (4 sources), decreased length of anterior-posterior axis (3 sources), abnormal anterior-posterior axis, curved dorsal (2 sources), abnormal bending of anterior-posterior axis (2 sources), abnormal convergent extension (2 sources), abnormal incomplete closing of the blastopore (2 sources), abnormal incomplete closing of the neural tube (2 sources), abnormal left/right axis specification (2 sources), abnormal neural tube closure (2 sources), abnormal small intestine morphology (2 sources), abnormally delayed closure of blastopore (2 sources), abnormally increased area of blastopore (2 sources), abnormally localised outflow tract (2 sources), decreased size of the head (2 sources), decreased size of the tail (2 sources), abnormal development of notochord (1 source), abnormal heart looping (1 source), decreased length of notochord (1 source)

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: zic3 manipulated (1 source), zic3 assayed (1 source)
Computed annotations: zic3 assayed (29 sources)

Experiments (Reagents) These are short form descriptions of experiments using reagents targeting the gene of interest.
Xla Wt + zic3 MO (14 sources), Xla Wt + zic3 MO (2 sources), Xla Wt + zic3 MO (1 source)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (40 sources): Abdominal situs inversus, Abnormal cardiovascular system morphology, Abnormal vertebral morphology, Abnormality of the vertebral column, Absence of the sacrum, Absent radius, Anal atresia, Asplenia, Atrial septal defect, Atrioventricular canal defect, Biliary atresia, Cardiomegaly, Common atrium, Cyanosis, Dextrocardia, Double outlet right ventricle, Enlarged kidney, Failure to thrive, Hand polydactyly, Horseshoe kidney, Hydrocephalus, Hydronephrosis, Hypertelorism, Isomerism, Low-set ears, Mitral atresia, Omphalocele, Patent ductus arteriosus, Polysplenia, Posteriorly placed anus, Proximal placement of thumb, Pulmonic stenosis, Renal agenesis, Respiratory distress, Short humerus, Single ventricle, Tracheoesophageal fistula, Transposition of the great arteries, Urethral atresia, Ventricular septal defect [+]
Mouse (71 sources): abnormal anterior primitive streak morphology, abnormal anterior visceral endoderm morphology, abnormal basal ganglion morphology, abnormal cerebral cortex morphology, abnormal diencephalon morphology, abnormal direction of heart looping, abnormal ear position, abnormal egg cylinder morphology, abnormal embryo development, abnormal embryo turning, abnormal embryonic epiblast morphology, abnormal embryonic neuroepithelial layer differentiation, abnormal embryonic tissue morphology, abnormal embryonic-extraembryonic boundary morphology, abnormal endoderm development, abnormal extraembryonic tissue morphology, abnormal gastrulation, abnormal heart development, abnormal heart looping, abnormal heart position or orientation, abnormal interfrontal bone morphology, abnormal left-right axis patterning, abnormal left-right axis symmetry of the somites, abnormal lung position or orientation, abnormal mandible morphology, abnormal mesoderm development, abnormal motile primary cilium morphology, abnormal neural plate morphology, abnormal neurocranium morphology, abnormal olfactory nerve morphology, abnormal primitive node morphology, abnormal primitive streak elongation, abnormal primitive streak morphology, abnormal rostral-caudal axis patterning, abnormal somite development, abnormal stomach position or orientation, abnormal zygomatic bone morphology, absent cerebellum, absent hyoid bone greater horns, absent primitive node, caudal body truncation, cranioschisis, decreased caudal vertebrae number, delayed neural tube closure, disorganized thalamus, embryonic growth arrest, embryonic growth retardation, embryonic lethality, complete penetrance, hemifacial hypoplasia, hindlimb paralysis, kinked tail, left pulmonary isomerism, lethality throughout fetal growth and development, incomplete penetrance, mandibular coronoid process hypoplasia, no abnormal phenotype detected, open neural tube, postnatal lethality, incomplete penetrance, premature death, prenatal lethality, complete penetrance, prenatal lethality, incomplete penetrance, preweaning lethality, incomplete penetrance, reduced fertility, right pulmonary isomerism, right-sided stomach, rostral-caudal axis duplication, short tail, situs ambiguus, situs inversus, small allantois, split notochord, vertebral transformation [+]
View all ortholog results at Monarch