Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.

Summary Expression Phenotypes Gene Literature (61) GO Terms (9) Nucleotides (179) Proteins (43) Interactants (1207) Wiki

fzd8     frizzled class receptor 8

Anatomical Phenotypes
Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.
abnormal gastrulation (3 sources), abnormal axis elongation (2 sources), abnormal head morphology (2 sources), abnormal tail morphology (2 sources), abnormally delayed closure of blastopore (2 sources), decreased length of anterior-posterior axis (2 sources), abnormal development of pronephric kidney (1 source), abnormal embryo morphology (1 source), abnormal incomplete closing of the neural tube (1 source), abnormal neural tube closure (1 source), abnormal pronephric kidney morphology (1 source), abnormal pronephric tubule morphology (1 source), decreased size of the head (1 source), decreased size of the tail (1 source)
Expression Phenotypes
Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: fzd8 manipulated (1 source)
Computed annotations: fzd8 assayed (27 sources)
Diseases from the human disease ontology (DO) manually associated with phenotypes from disease models. Sources are grouped by anatomical (AP) and expression (EP) phenotypes.
nephronophthisis 2 (2AP sources)
Experiments (Reagents)
These are short form descriptions of experiments using reagents targeting the gene of interest.
Xla Wt + fzd8 MO (2 sources), Xtr Wt + fzd8 MO (2 sources), Xtr Wt + fzd8 MO (2 sources), Xla Wt + fzd8 MO (1 source)
Monarch Ortholog Phenotypes
These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Mouse (4 sources): increased cardiac muscle contractility, increased heart left ventricle size, no abnormal phenotype detected, thick ventricular wall