| Monarch Ortholog Phenotypes
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Human (29 sources):
Anorexia,
Constipation,
Enuresis nocturna,
Failure to thrive,
Feeding difficulties,
Feeding difficulties in infancy,
Fever,
Functional abnormality of the bladder,
Global developmental delay,
Growth delay,
Hydroureter,
Hypernatremia,
Hypernatremic dehydration,
Hypertonic dehydration,
Hyposthenuria,
Hypovolemia,
Intellectual disability,
Irritability,
Megacystis,
Nausea and vomiting,
Nephrogenic diabetes insipidus,
Polydipsia,
Polyhydramnios,
Polyuria,
Renal insufficiency,
Seizure,
Short stature,
Unexplained fevers,
Vomiting
[+]
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Mouse (21 sources):
abnormal coat appearance,
abnormal kidney morphology,
abnormal kidney pelvis morphology,
abnormal kidney pyramid morphology,
abnormal urine osmolality,
colorless urine,
decreased body size,
decreased urine osmolality,
dilated kidney calyx,
dilated kidney collecting duct,
dilated renal tubules,
increased blood osmolality,
kidney collecting duct atrophy,
kidney medulla atrophy,
kidney medulla cyst,
kidney papillary atrophy,
postnatal lethality, complete penetrance,
postnatal lethality, incomplete penetrance,
premature death,
reduced fertility,
reproductive system phenotype
[+]
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View all ortholog results at Monarch
|
Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.