timp3 Phenotypes

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Phenotypes

Gene Literature (7)

Nucleotides (109)

Interactants (184)

XB-GENEPAGE-482399

Gene Symbol: timp3 Gene Name: TIMP metallopeptidase inhibitor 3

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Computed annotations: timp3 assayed (11 sources)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (4 sources): Abnormal electroretinogram, Blindness, Glaucoma, Macular dystrophy
Mouse (59 sources): abdominal aorta aneurysm, abnormal Bruch membrane morphology, abnormal abdominal aorta morphology, abnormal aorta wall morphology, abnormal apoptosis, abnormal artery morphology, abnormal blood vessel elastic tissue morphology, abnormal blood vessel physiology, abnormal branching involved in terminal bronchiole morphogenesis, abnormal bronchiole morphology, abnormal cardiac muscle relaxation, abnormal choroid vasculature morphology, abnormal involution of the mammary gland, abnormal kidney morphology, abnormal lactation, abnormal learning/memory/conditioning, abnormal liver lobule morphology, abnormal pulmonary alveolus morphology, abnormal pulmonary alveolus wall morphology, abnormal retina blood vessel morphology, abnormal retina pigment epithelium morphology, abnormal spatial learning, abnormal systemic arterial blood pressure, abnormal vascular branching morphogenesis, aortitis, behavior/neurological phenotype, cardiac fibrosis, cardiac hypertrophy, cardiovascular system phenotype, cellular phenotype, decreased cardiac muscle contractility, decreased circulating glucose level, decreased lean body mass, decreased left ventricle developed pressure, decreased left ventricle systolic pressure, decreased susceptibility to induced hypothermia, decreased systemic arterial blood pressure, decreased vasodilation, decreased ventricle muscle contractility, dilated heart left ventricle, dilated terminal bronchiole tube, endocrine/exocrine gland phenotype, hunched posture, impaired liver regeneration, impaired lung alveolus development, increased body temperature, increased carbon dioxide production, increased hepatocyte apoptosis, increased oxygen consumption, increased response of heart to induced stress, increased sensitivity to induced morbidity/mortality, increased startle reflex, increased susceptibility to injury, increased tumor necrosis factor secretion, overexpanded pulmonary alveoli, premature death, renal/urinary system phenotype, respiratory system phenotype, ruffled hair [+]
View all ortholog results at Monarch