smad2 Phenotypes

Summary

Expression

Phenotypes

Gene Literature (244)

XB-GENEPAGE-482929

Gene Symbol: smad2 Gene Name: SMAD family member 2

Anatomical Phenotypes Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.
abnormally ventralized embryo (2 sources), decreased length of anterior-posterior axis (2 sources), abnormal axis elongation (1 source), abnormal bending of anterior-posterior axis (1 source), abnormal bending of tail (1 source), abnormal development of embryo (1 source), abnormal gastrulation (1 source), abnormal head morphology (1 source), abnormal tail morphology (1 source), absent cement gland (1 source), decreased length of tail (1 source), decreased size of the tail (1 source), obsolete duplicated dorsal-ventral axis (1 source)

Anatomical Phenotypes

Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.

abnormally ventralized embryo (2 sources), decreased length of anterior-posterior axis (2 sources), abnormal axis elongation (1 source), abnormal bending of anterior-posterior axis (1 source), abnormal bending of tail (1 source), abnormal development of embryo (1 source), abnormal gastrulation (1 source), abnormal head morphology (1 source), abnormal tail morphology (1 source), absent cement gland (1 source), decreased length of tail (1 source), decreased size of the tail (1 source), obsolete duplicated dorsal-ventral axis (1 source)

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: smad2 manipulated (9 sources)
Computed annotations: smad2 assayed (1 source)

Experiments (Reagents) These are short form descriptions of experiments using reagents targeting the gene of interest.
Xtr Wt + smad2 MO (3 sources), Xla Wt + smad2 + animal cap explant (2 sources), Xla Wt + dnsmad2 (1 source), Xla Wt + foxh1 + smad2 (1 source), Xla Wt + pias4 + smad2 + animal cap explant (1 source), Xla Wt + smad2 (1 source), Xla Wt + smad2 (1 source), Xla Wt + smad2 (1 source), Xla Wt + smad2 + animal cap explant (1 source), Xla Wt + smad2 MO (1 source), Xla Wt + smad2 MO (1 source), Xla Wt + smad2-VP16 (1 source)

Experiments (Reagents)

These are short form descriptions of experiments using reagents targeting the gene of interest.

Xtr Wt + smad2 MO (3 sources), Xla Wt + smad2 + animal cap explant (2 sources), Xla Wt + dnsmad2 (1 source), Xla Wt + foxh1 + smad2 (1 source), Xla Wt + pias4 + smad2 + animal cap explant (1 source), Xla Wt + smad2 (1 source), Xla Wt + smad2 (1 source), Xla Wt + smad2 (1 source), Xla Wt + smad2 + animal cap explant (1 source), Xla Wt + smad2 MO (1 source), Xla Wt + smad2 MO (1 source), Xla Wt + smad2-VP16 (1 source)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Mouse (82 sources): abnormal anterior definitive endoderm morphology, abnormal cell differentiation, abnormal cell migration, abnormal cell morphology, abnormal cerebellar foliation, abnormal cerebellar granule cell migration, abnormal cerebellar granule cell morphology, abnormal cerebellum vermis lobule IX morphology, abnormal cerebellum vermis lobule X morphology, abnormal chorion morphology, abnormal craniofacial morphology, abnormal developmental patterning, abnormal dorsal aorta morphology, abnormal ectoplacental cone morphology, abnormal egg cylinder morphology, abnormal embryonic epiblast morphology, abnormal embryonic-extraembryonic boundary morphology, abnormal embryonic tissue morphology, abnormal extraembryonic endoderm formation, abnormal extraembryonic tissue morphology, abnormal eye development, abnormal forebrain development, abnormal heart development, abnormal heart looping, abnormal heart tube morphology, abnormal hindbrain development, abnormal locomotor coordination, abnormal mandible morphology, abnormal Meckel's cartilage morphology, abnormal primitive streak elongation, abnormal proamniotic cavity morphology, abnormal proximal-distal axis patterning, abnormal Purkinje cell dendrite morphology, abnormal rostral-caudal axis patterning, abnormal visceral endoderm morphology, abnormal wound healing, absent allantois, absent amnion, absent chorion, absent ectoderm, absent endoderm, absent extraembryonic ectoderm, absent forebrain, absent foregut, absent head fold, absent mandible, absent mesoderm, absent notochord, absent optic placodes, absent primitive node, decreased body size, decreased CNS synapse formation, decreased embryo size, embryonic growth arrest, embryonic growth retardation, embryonic lethality between implantation and somite formation, complete penetrance, embryonic lethality, complete penetrance, embryonic lethality during organogenesis, embryonic lethality during organogenesis, complete penetrance, enhanced wound healing, enlarged pericardium, failure of chorioallantoic fusion, failure of primitive streak formation, failure to gastrulate, impaired balance, increased cell proliferation, increased keratinocyte migration, increased neuron apoptosis, limb grasping, liver/biliary system phenotype, mandible hypoplasia, neonatal lethality, incomplete penetrance, nervous system phenotype, no abnormal phenotype detected, pericardial edema, premature death, prenatal lethality, incomplete penetrance, reproductive system phenotype, rostral body truncation, short stride length, slow postnatal weight gain, truncated foregut [+]

Monarch Ortholog Phenotypes

These phenotypes are associated with this gene with a has phenotype relation via Monarch.

Mouse (82 sources): abnormal anterior definitive endoderm morphology, abnormal cell differentiation, abnormal cell migration, abnormal cell morphology, abnormal cerebellar foliation, abnormal cerebellar granule cell migration, abnormal cerebellar granule cell morphology, abnormal cerebellum vermis lobule IX morphology, abnormal cerebellum vermis lobule X morphology, abnormal chorion morphology, [+]