bmp4 Phenotypes

Summary

Expression

Phenotypes

Gene Literature (640)

XB-GENEPAGE-483057

Gene Symbol: bmp4 Gene Name: bone morphogenetic protein 4

Anatomical Phenotypes Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.
partially ventralized embryo (3 sources), wholly ventralized embryo (2 sources), abnormal tail morphology (1 source), abnormal ventral trunk morphology (1 source), decreased size of the embryo (1 source), decreased size of the head (1 source), edematous ventral trunk (1 source), wholly dorsalized tadpole (1 source)

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: bmp4 manipulated (20 sources), bmp4 assayed (14 sources)
Computed annotations: bmp4 manipulated (1 source), bmp4 assayed (10 sources)

Experiments (Reagents) These are short form descriptions of experiments using reagents targeting the gene of interest.
Xla Wt + bmp4 (3 sources), Xla Wt + bmp4 MO (3 sources), Xla Wt + bmp4 (2 sources), Xla Wt + bmp4 + animal cap explant (2 sources), Xla Wt + bmp4 + CHX + animal cap explant (2 sources), Xla Wt + Hsa.BMP4 (2 sources), Xla Wt + dnbmp4 (2 sources), Xtr Wt + bmp4 (2 sources), Xtr Wt + bmp4 MO (2 sources), Xla Wt + bmp4 (1 source), Xla Wt + bmp4 + animal cap explant (1 source), Xla Wt + bmp4 + animal cap explant (1 source), Xla Wt + bmp4 + animal cap explant (1 source), Xla Wt + bmp4 + rspo2 + animal cap explant (1 source), Xla Wt + Hsa.BMP4 (1 source)

Experiments (Reagents)

These are short form descriptions of experiments using reagents targeting the gene of interest.

Xla Wt + bmp4 (3 sources), Xla Wt + bmp4 MO (3 sources), Xla Wt + bmp4 (2 sources), Xla Wt + bmp4 + animal cap explant (2 sources), Xla Wt + bmp4 + CHX + animal cap explant (2 sources), Xla Wt + Hsa.BMP4 (2 sources), Xla Wt + dnbmp4 (2 sources), Xtr Wt + bmp4 (2 sources), Xtr Wt + bmp4 MO (2 sources), Xla Wt + bmp4 (1 source), Xla Wt + bmp4 + animal cap explant (1 source), Xla Wt + bmp4 + animal cap explant (1 source), Xla Wt + bmp4 + animal cap explant (1 source), Xla Wt + bmp4 + rspo2 + animal cap explant (1 source), Xla Wt + Hsa.BMP4 (1 source)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (82 sources): Abnormal cerebral white matter morphology, Abnormality of the cervical spine, Abnormality of the ear, Abnormality of the genital system, Abnormality of the hand, Abnormality of the hypothalamus-pituitary axis, Abnormality of the skeletal system, Absent speech, Adrenal hypoplasia, Agenesis of corpus callosum, Anophthalmia, Anterior hypopituitarism, Aplasia of the optic tract, Aplasia/Hypoplasia of the corpus callosum, Bifid scrotum, Bifid uvula, Blindness, Brachycephaly, Brachydactyly, Cataract, Cerebellar hypoplasia, Cerebral cortical atrophy, Chorioretinal coloboma, Cleft lip, Cleft palate, Clinodactyly of the 5th finger, Coloboma, Cryptorchidism, Delayed CNS myelination, Facial asymmetry, Failure to thrive, Female hypogonadism, Finger syndactyly, Flexion contracture of thumb, Global developmental delay, Hearing impairment, High forehead, High palate, Hypospadias, Hypothyroidism, Hypotonia, Inferior cerebellar vermis hypoplasia, Iris coloboma, Lambdoidal craniosynostosis, Low-set ears, Macrotia, Malar flattening, Microcephaly, Microcornea, Microglossia, Micrognathia, Micropenis, Microphthalmia, Midface retrusion, Morphological central nervous system abnormality, Myopia, Nail dysplasia, Nystagmus, Orbital cyst, Orofacial cleft, Plagiocephaly, Polydactyly, Postaxial foot polydactyly, Posteriorly rotated ears, Preaxial hand polydactyly, Protruding ear, Proximal placement of thumb, Psychomotor retardation, Renal hypoplasia, Retinal dystrophy, Retrognathia, Sclerocornea, Seizure, Sensorineural hearing impairment, Severe muscular hypotonia, Short middle phalanx of finger, Single transverse palmar crease, Small sella turcica, Toe syndactyly, Uplifted earlobe, Ventriculomegaly, obsolete Small scrotum [+]
Mouse (162 sources): abnormal Wolffian duct morphology, abnormal allantois morphology, abnormal amniotic cavity morphology, abnormal angiogenesis, abnormal aortic arch and aortic arch branch attachment, abnormal artery morphology, abnormal atrioventricular cushion morphology, abnormal canal of Schlemm morphology, abnormal cardiac mesenchyme morphology, abnormal cardiac outflow tract development, abnormal chorion morphology, abnormal conotruncal ridge morphology, abnormal ear development, abnormal embryo size, abnormal embryo turning, abnormal embryonic cloaca development, abnormal endolymphatic duct morphology, abnormal external female genitalia morphology, abnormal extraembryonic mesoderm development, abnormal eye development, abnormal eye electrophysiology, abnormal eye size, abnormal face development, abnormal fertility/fecundity, abnormal forebrain development, abnormal foregut morphology, abnormal forelimb morphology, abnormal head mesenchyme morphology, abnormal heart and great artery attachment, abnormal heart development, abnormal heart looping, abnormal heart right ventricle pressure, abnormal hindbrain development, abnormal hindlimb bud morphology, abnormal iridocorneal angle, abnormal kidney development, abnormal kidney mesenchyme morphology, abnormal lateral plate mesoderm morphology, abnormal lens induction, abnormal limb development, abnormal line of Schwalbe morphology, abnormal liver bud morphology, abnormal mandible morphology, abnormal mesoderm development, abnormal metanephric mesenchyme morphology, abnormal midbrain development, abnormal motor capabilities/coordination/movement, abnormal muscle fiber morphology, abnormal nephrogenic zone morphology, abnormal organ of Corti morphology, abnormal pharyngeal arch artery morphology, abnormal placenta development, abnormal placenta morphology, abnormal posterior primitive streak morphology, abnormal primitive node morphology, abnormal prostate gland anterior lobe morphology, abnormal radial glial cell morphology, abnormal renal glomerulus morphology, abnormal renal/urinary system morphology, abnormal retina blood vessel pattern, abnormal retina photoreceptor layer morphology, abnormal rostral-caudal axis patterning, abnormal scala media morphology, abnormal secondary palate development, abnormal semicircular canal ampulla morphology, abnormal semilunar valve morphology, abnormal seminiferous tubule morphology, abnormal sensory neuron innervation pattern, abnormal snout morphology, abnormal tail morphology, abnormal temporomandibular joint morphology, abnormal truncus arteriosus septation, abnormal ureter development, abnormal ureter smooth muscle morphology, abnormal ureteral orifice morphology, abnormal ureteric bud elongation, abnormal ureterovesical junction morphology, abnormal vascular endothelial cell physiology, abnormal vascular smooth muscle morphology, abnormal vertebral spinous process morphology, abnormal vestibulocollic reflex, abnormal visceral yolk sac mesenchyme morphology, abnormal visceral yolk sac morphology, abnormal vitreous body morphology, absent Rathke's pouch, absent Schlemm's canal, absent allantois, absent lateral semicircular canal, absent mandibular angle, absent mandibular condyloid process, absent mandibular coronoid process, absent primordial germ cells, absent trabecular meshwork, absent urinary bladder, absent visceral yolk sac blood islands, agnathia, behavior/neurological phenotype, cardiovascular system phenotype, circling, common atrioventricular valve, conotruncal ridge hypoplasia, decreased erythrocyte cell number, decreased lateral semicircular canal size, decreased litter size, decreased oligodendrocyte number, decreased primordial germ cell number, decreased retina inner nuclear layer thickness, decreased vestibular hair cell stereocilia number, delayed hepatic development, dilated kidney calyx, dilated ureter, duplex kidney, ectopic bone, ectopic ureter, ectopic ureteric bud, embryonic growth retardation, embryonic lethality between implantation and somite formation, complete penetrance, embryonic lethality during organogenesis, complete penetrance, embryonic lethality during organogenesis, incomplete penetrance, embryonic lethality prior to tooth bud stage, embryonic lethality, complete penetrance, enhanced osteoblast differentiation, eyelids fail to open, eyelids open at birth, failure of primitive streak formation, failure of ventral body wall closure, hearing/vestibular/ear phenotype, hypoplastic trabecular meshwork, impaired osteoblast differentiation, increased astrocyte number, increased circulating glucose level, increased metanephric mesenchyme apoptosis, increased or absent threshold for auditory brainstem response, irregularly shaped pupil, lethality throughout fetal growth and development, incomplete penetrance, limb grasping, limbs/digits/tail phenotype, mandible hypoplasia, nervous system phenotype, ocular hypertension, opacity of vitreous body, palatal shelf fusion with tongue or mandible, palatal shelf hypoplasia, palatal shelves fail to meet at midline, partial atrioventricular septal defect, perinatal lethality, complete penetrance, perinatal lethality, incomplete penetrance, persistence of hyaloid vascular system, postnatal lethality, postnatal lethality, complete penetrance, postnatal lethality, incomplete penetrance, prenatal lethality, complete penetrance, prenatal lethality, incomplete penetrance, preweaning lethality, complete penetrance, reduced female fertility, seminiferous tubule degeneration, short frontal bone, small allantois, small interparietal bone, small kidney, syngnathia, thin retina ganglion layer [+]
View all ortholog results at Monarch