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Summary Expression Phenotypes Gene Literature (82) GO Terms (10) Nucleotides (60) Proteins (36) Interactants (422) Wiki

pdx1     pancreatic and duodenal homeobox 1

Anatomical Phenotypes
Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.
increased size of the pancreas (2 sources), abnormal bending of tail (1 source), abnormal dorsal fin margin morphology (1 source), abnormal duodenum morphology (1 source), abnormal stomach morphology (1 source), abnormal ventral fin margin morphology (1 source), decreased size of the duodenum (1 source), decreased size of the stomach (1 source)
Expression Phenotypes
Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: pdx1 manipulated (4 sources), pdx1 assayed (35 sources)
Computed annotations: pdx1 assayed (5 sources)
Experiments (Reagents)
These are short form descriptions of experiments using reagents targeting the gene of interest.
Xla Wt + pdx1-GR + ptf1a-GR + DEX (4 sources), Xla Wt + pdx1 MO (1 source), Xla Wt + pdx1 MO + ptf1a MO (1 source)
Monarch Ortholog Phenotypes
These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (73 sources): Abnormal C-peptide level, Abnormal heart morphology, Abnormal insulin level, Abnormal oral glucose tolerance, Abnormality of the ear, Abnormality of the genitourinary system, Abnormality of the immune system, Abnormality of the kidney, Abnormality of the upper urinary tract, Anteverted nares, [+]
Mouse (52 sources): abnormal PP cell morphology, abnormal bile duct development, abnormal duodenum morphology, abnormal embryo size, abnormal enteroendocrine cell morphology, abnormal foregut morphology, abnormal liver development, abnormal mitochondrial physiology, abnormal pancreas development, abnormal pancreatic acinar cell morphology, [+]

View all ortholog results at Monarch