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Summary Expression Phenotypes Gene Literature (13) GO Terms (7) Nucleotides (321) Proteins (50) Interactants (217) Wiki

rab7a     RAB7A, member RAS oncogene family

Anatomical Phenotypes
Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.
abnormal gastrulation (2 sources), abnormal tail morphology (2 sources), decreased length of tail (2 sources), decreased length of trunk (2 sources), decreased size of the main body axis (2 sources), abnormal MAP kinase activity (1 source), abnormal convergent extension involved in axis elongation (1 source), abnormal dorsal fin (1 source), abnormal embryo morphology (1 source), abnormal foregut endoderm (1 source), abnormal somite morphology (1 source), abnormal upper blastopore lip morphology (1 source), absent notochord (1 source), decreased size of the ventral fin margin (1 source), whole organism abnormally curved dorsally (1 source)
Expression Phenotypes
Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: rab7a manipulated (15 sources), rab7a assayed (2 sources)
Experiments (Reagents)
These are short form descriptions of experiments using reagents targeting the gene of interest.
Xla Wt + rab7a MO (11 sources), Xla Wt + rab7a MO (9 sources), Xla Wt + rab7a MO (0.8pmol) (1 source)
Monarch Ortholog Phenotypes
These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (20 sources): Areflexia, Autoamputation, Autoamputation of foot, Axonal degeneration/regeneration, Decreased motor nerve conduction velocity, Decreased number of peripheral myelinated nerve fibers, Distal amyotrophy, Distal muscle weakness, Dystrophic toenail, Foot dorsiflexor weakness, [+]
Mouse (12 sources): abnormal T cell subpopulation ratio, abnormal autophagy, abnormal primitive streak elongation, abnormal visceral endoderm morphology, decreased CD4-positive, alpha beta T cell number, decreased T cell proliferation, embryonic lethality, failure to gastrulate, increased mitochondrial size, lethality, incomplete penetrance, [+]

View all ortholog results at Monarch