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XB-GENEPAGE-483563
rab7a RAB7A, member RAS oncogene family
Anatomical Phenotypes
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abnormal gastrulation (2 sources), abnormal tail morphology (2 sources), decreased length of tail (2 sources), decreased length of trunk (2 sources), decreased size of the main body axis (2 sources), abnormal MAP kinase activity (1 source), abnormal convergent extension involved in axis elongation (1 source), abnormal dorsal fin (1 source), abnormal embryo morphology (1 source), abnormal foregut endoderm (1 source), abnormal somite morphology (1 source), abnormal upper blastopore lip morphology (1 source), absent notochord (1 source), decreased size of the ventral fin margin (1 source), whole organism abnormally curved dorsally (1 source) |
Expression Phenotypes
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Manual annotations: rab7a manipulated (15 sources), rab7a assayed (2 sources) |
Experiments (Reagents)
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Xla Wt + rab7a MO (11 sources), Xla Wt + rab7a MO (9 sources), Xla Wt + rab7a MO (0.8pmol) (1 source) |
Monarch Ortholog Phenotypes
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Human (20 sources): Areflexia, Autoamputation, Autoamputation of foot, Axonal degeneration/regeneration, Decreased motor nerve conduction velocity, Decreased number of peripheral myelinated nerve fibers, Distal amyotrophy, Distal muscle weakness, Dystrophic toenail, Foot dorsiflexor weakness, [+] |
Mouse (12 sources): abnormal T cell subpopulation ratio, abnormal autophagy, abnormal primitive streak elongation, abnormal visceral endoderm morphology, decreased CD4-positive, alpha beta T cell number, decreased T cell proliferation, embryonic lethality, failure to gastrulate, increased mitochondrial size, lethality, incomplete penetrance, [+] |
View all ortholog results at Monarch |