Monarch Ortholog Phenotypes
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Human (27 sources):
Abnormal cardiac septum morphology,
Autistic behavior,
Broad forehead,
Broad nasal tip,
Delayed ability to walk,
Delayed myelination,
Delayed speech and language development,
Epicanthus,
Feeding difficulties,
Generalized hypotonia,
Global developmental delay,
High palate,
Hypertelorism,
Hypoplasia of the brainstem,
Hypoplasia of the corpus callosum,
Macrocephaly,
Megalocornea,
Microcephaly,
Periorbital fullness,
Plagiocephaly,
Proptosis,
Seizure,
Short philtrum,
Single transverse palmar crease,
Umbilical hernia,
Ventriculomegaly,
Visual impairment
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Mouse (26 sources):
abnormal T cell subpopulation ratio,
abnormal cauda epididymis morphology,
abnormal embryo development,
abnormal embryonic tissue morphology,
abnormal erythropoiesis,
abnormal seminiferous tubule morphology,
absent mesoderm,
arrest of male meiosis,
cardiovascular system phenotype,
decreased embryo size,
decreased fetal derived definitive erythrocyte cell number,
decreased testis weight,
embryo phenotype,
embryonic lethality between implantation and somite formation, complete penetrance,
embryonic lethality during organogenesis, complete penetrance,
embryonic lethality during organogenesis, incomplete penetrance,
enlarged lymph nodes,
increased germinal center B cell number,
increased hematopoietic stem cell number,
increased interleukin-17 secretion,
increased neutrophil cell number,
increased susceptibility to injury,
lethality throughout fetal growth and development, incomplete penetrance,
no abnormal phenotype detected,
pale liver,
seminiferous tubule degeneration
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View all ortholog results at Monarch
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