sfrp2 Phenotypes

Phenotypes

XB-GENEPAGE-485146

Gene Symbol: sfrp2 Gene Name: secreted frizzled-related protein 2

Anatomical Phenotypes Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.
abnormal incomplete closing of the neural tube (3 sources), abnormal neural tube closure (3 sources), decreased length of anterior-posterior axis (3 sources)

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: sfrp2 manipulated (3 sources)
Computed annotations: sfrp2 assayed (19 sources)

Experiments (Reagents) These are short form descriptions of experiments using reagents targeting the gene of interest.
Xla Wt + sfrp2 MO (3 sources), Xla Wt + Hsa.sfrp2 (1 source), Xla Wt + Hsa.sfrp2 (1 source), Xla Wt + sfrp2 (1 source)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Mouse (21 sources): abnormal caudal vertebrae morphology, abnormal chondrocyte physiology, abnormal digit development, abnormal interdigital cell death, abnormal long bone diaphysis morphology, abnormal neuron differentiation, abnormal response of heart to induced stress, abnormal retina vasculature morphology, abnormal tail movements, abnormal vertebral epiphyseal plate morphology, brachypodia, decreased lean body mass, delayed endochondral bone ossification, increased cardiac muscle contractility, increased startle reflex, kinked tail, limbs/digits/tail phenotype, no abnormal phenotype detected, polysyndactyly, reproductive system phenotype, short radius [+]

Monarch Ortholog Phenotypes

These phenotypes are associated with this gene with a has phenotype relation via Monarch.

Mouse (21 sources): abnormal caudal vertebrae morphology, abnormal chondrocyte physiology, abnormal digit development, abnormal interdigital cell death, abnormal long bone diaphysis morphology, abnormal neuron differentiation, abnormal response of heart to induced stress, abnormal retina vasculature morphology, abnormal tail movements, abnormal vertebral epiphyseal plate morphology, [+]