| Monarch Ortholog Phenotypes
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Human (13 sources):
Abnormal autonomic nervous system physiology,
Attention deficit hyperactivity disorder,
Autistic behavior,
Cognitive impairment,
Global developmental delay,
Glucose intolerance,
Hyperinsulinemia,
Hypotension,
Low levels of vitamin B1,
Memory impairment,
[+]
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Mouse (20 sources):
abnormal brown adipose tissue morphology,
abnormal diencephalon morphology,
abnormal energy homeostasis,
abnormal nervous system tract morphology,
abnormal paraventricular hypothalamic nucleus morphology,
abnormal pituicyte morphology,
abnormal supraoptic nucleus morphology,
abnormal white adipose tissue morphology,
absent magnocellular neurosecretory cells,
decreased apoptosis,
increased body length,
increased brown adipose tissue amount,
increased circulating glucose level,
increased susceptibility to diet-induced obesity,
increased susceptibility to weight gain,
increased total body fat amount,
increased white adipose tissue amount,
neonatal lethality, complete penetrance,
nervous system phenotype,
no abnormal phenotype detected
[+]
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View all ortholog results at Monarch
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Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.