| Monarch Ortholog Phenotypes
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Human (15 sources):
Abnormality of metabolism/homeostasis,
Abnormality of the Leydig cells,
Abnormal spermatogenesis,
Androgen insufficiency,
Decreased circulating luteinizing hormone level,
Decreased serum testosterone concentration,
Gynecomastia,
Hypogonadotropic hypogonadism,
Micropenis,
Oligomenorrhea,
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Mouse (23 sources):
abnormal female reproductive system morphology,
abnormal gametogenesis,
abnormal Leydig cell differentiation,
abnormal male germ cell apoptosis,
abnormal ovarian follicle morphology,
abnormal sex gland secretion,
abnormal spermatid morphology,
absent corpus luteum,
absent estrous cycle,
absent ovarian follicles,
arrest of spermatogenesis,
decreased circulating estradiol level,
decreased circulating progesterone level,
decreased Leydig cell number,
decreased oocyte number,
small bulbourethral gland,
small epididymis,
small external male genitalia,
small ovary,
small prostate gland,
small seminal vesicle,
small vulva,
thin endometrium
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View all ortholog results at Monarch
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Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.