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Summary Expression Phenotypes Gene Literature (613) GO Terms (4) Nucleotides (172) Proteins (63) Interactants (2023) Wiki
XB-GENEPAGE-486770

gsc     goosecoid homeobox

Anatomical Phenotypes
Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.
abnormal eye morphology (5 sources), absent eye (5 sources), absent head (4 sources), duplicated main body axis (4 sources), abnormal embryo morphology (3 sources), duplicated head (3 sources), abnormal head morphology (2 sources), abnormal retina morphology (2 sources), decreased length of tail (2 sources), decreased size of the eye (2 sources), fused eyes (2 sources), abnormal forebrain (1 source), abnormal foregut morphology (1 source), abnormal tail morphology (1 source), absent optic stalk (1 source), decreased size of the forebrain (1 source), decreased size of the midbrain-hindbrain boundary (1 source), duplicated eye (1 source)
Expression Phenotypes
Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: gsc manipulated (6 sources), gsc assayed (55 sources)
Computed annotations: gsc assayed (44 sources)
Experiments (Reagents)
These are short form descriptions of experiments using reagents targeting the gene of interest.
Xla Wt + gsc MO (3 sources), Xla Wt + tle1 + gsc + otx2 + ssbp3 + ldb1 + lhx1 mRNA (3 sources), Xtr Wt + otx2 MO + crx MO + gsc MO + lhx1 MO (3 sources), Xbo Wt + gsc MO + cdx1 MO (VMZ) (1 source), Xla Wt + gsc (1 source), Xla Wt + gsc (1 source), Xla Wt + gsc + ssbp3 + tle1 + lhx1 mRNA 5 (1 source), Xla Wt + gsc MO (1 source), Xla Wt + gsc MO + cdx1 MO (DMZ) (1 source), Xla Wt + tle1 + otx2 + gsc mRNA (1 source), Xtr Wt + gsc MO (1 source), Xtr Wt + gsc MO + crx MO + otx2 MO (1 source), Xtr Wt + lhx1 MO + gsc MO (1 source)
Monarch Ortholog Phenotypes
These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (22 sources): Atresia of the external auditory canal, Conductive hearing impairment, Cryptorchidism, Deeply set eye, Delayed ossification of pubic rami, Dislocated radial head, Downslanted palpebral fissures, Feeding difficulties, Flexion contracture, High palate, [+]
Mouse (62 sources): abnormal Meckel's cartilage morphology, abnormal acetabulum morphology, abnormal alisphenoid bone morphology, abnormal basicranium morphology, abnormal breathing pattern, abnormal craniofacial morphology, abnormal epitympanic recess morphology, abnormal ethmoid bone morphology, abnormal external auditory canal morphology, abnormal extrinsic tongue muscle morphology, [+]

View all ortholog results at Monarch