Abnormality of bone marrow cell morphology, Abnormality of metabolism/homeostasis, Abnormality of retinal pigmentation, Abnormality of the abdominal wall, Abnormality of the frontal bone, Abnormality of the hepatic vasculature, Abnormality of the liver, Abnormality of the musculature, Abnormality of the orbital region, Abnormality of the upper urinary tract, Adenomatous colonic polyposis, Aggressive behavior, Anasarca, Anemia, Anorexia, Arthralgia, Ascites, Ataxia, Autistic behavior, Axial hypotonia, Back pain, Behavioral abnormality, Bilateral sensorineural hearing impairment, Bitemporal hemianopia, Bone pain, Breast carcinoma, Broad nasal tip, Budd-Chiari syndrome, Central adrenal insufficiency, Central diabetes insipidus, Cerebellar ataxia associated with quadrupedal gait, Cerebellar calcifications, Cerebellar cyst, Cerebellar hemorrhage, Cerebellar medulloblastoma, Cerebral calcification, Cerebral ischemia, Chest pain, Cognitive impairment, Colon cancer, Coma, Constitutional symptom, Delayed CNS myelination, Delayed cranial suture closure, Delayed puberty, Desmoid tumors, Developmental regression, Diarrhea, Diplopia, Dysgerminoma, Dysmetria, Dyspnea, Elevated circulating hepatic transaminase concentration, Enlarged pituitary gland, Epidermoid cyst, Epigastric pain, Esophageal varix, Excessive daytime somnolence, Exudative vitreoretinopathy, Failure to thrive, Fatigue, Fever, Fibroma, Gastrointestinal hemorrhage, Generalized hypopigmentation, Generalized hypotonia, Global developmental delay, Growth delay, Headache, Hearing impairment, Hemobilia, Hepatic encephalopathy, Hepatic necrosis, Hepatocellular carcinoma, Hepatomegaly, Hereditary nonpolyposis colorectal carcinoma, High palate, Hydrocephalus, Hydronephrosis, Hyperbilirubinemia, Hypercalcemia, Hypermetropia, Hypoalbuminemia, Hypoglycemia, Hypogonadism, Hypogonadotropic hypogonadism, Hypokalemia, Hyponatremia, Hypopituitarism, Hypoplasia of the corpus callosum, Hypotension, Hypotonia, Increased circulating prolactin concentration, Increased intracranial pressure, Increased susceptibility to fractures, Intellectual disability, Intention tremor, Internal hemorrhage, Intestinal obstruction, Intestinal polyposis, Intracranial cystic lesion, Irritability, Jaundice, Lethargy, Limitation of joint mobility, Liver abscess, Long philtrum, Low hanging columella, Malabsorption, Medulloblastoma, Metabolic alkalosis, Microcephaly, Micronodular cirrhosis, Motor delay, Myalgia, Myocardial infarction, Myopia, Nausea and vomiting, Neoplasm, Neoplasm of the anterior pituitary, Neoplasm of the lung, Neoplasm of the skin, Neoplasm of the stomach, Neuroblastoma, Neurological speech impairment, Nystagmus, Obesity, Optic atrophy, Osteolysis, Ovarian papillary adenocarcinoma, Papilledema, Pedal edema, Pilomatrixoma, Pituitary hypothyroidism, Polycythemia, Polyphagia, Poor appetite, Poor speech, Portal hypertension, Primary microcephaly, Progressive cerebellar ataxia, Progressive macrocephaly, Progressive visual field defects, Progressive visual loss, Proportionate short stature, Recurrent infections, Renal cell carcinoma, Retinal degeneration, Retinal hole, Seizure, Self-injurious behavior, Sepsis, Sleep apnea, Sleep disturbance, Slow decrease in visual acuity, Smooth philtrum, Spastic diplegia, Spasticity, Spinal cord tumor, Strabismus, Subacute progressive viral hepatitis, Subcutaneous nodule, Sudden loss of visual acuity, Syringomyelia, Tethered cord, Thin upper lip vermilion, Thrombocytopenia, Thrombocytosis, Total ophthalmoplegia, Transitional cell carcinoma of the bladder, Type II diabetes mellitus, Underdeveloped nasal alae, Uterine leiomyosarcoma, Venous insufficiency, Ventriculomegaly, Vertigo, Vitreoretinopathy, Weight loss, obsolete Mood changes

abnormal cerebral cortex morphology, abnormal chondrocyte morphology, abnormal craniofacial bone morphology, abnormal craniofacial development, abnormal craniofacial morphology, abnormal cranium morphology, abnormal crypts of Lieberkuhn morphology, abnormal dental mesenchyme morphology, abnormal dermis papillary layer morphology, abnormal developmental patterning, abnormal dorsal root ganglion morphology, abnormal ectoderm development, abnormal embryonic epiblast morphology, abnormal embryonic tissue morphology, abnormal enamel knot morphology, abnormal endocardium morphology, abnormal exocrine pancreas morphology, abnormal external female genitalia morphology, abnormal external male genitalia morphology, abnormal extraembryonic tissue morphology, abnormal face development, abnormal filiform papillae morphology, abnormal forebrain development, abnormal forelimb morphology, abnormal foreskin morphology, abnormal gastrulation, abnormal germ layer development, abnormal globus pallidus morphology, abnormal hair cycle anagen phase, abnormal hair follicle development, abnormal hair follicle infundibulum morphology, abnormal hair follicle melanogenesis, abnormal hair follicle morphology, abnormal head size, abnormal hindlimb morphology, abnormal hippocampus neuron morphology, abnormal humerus morphology, abnormal inner cell mass morphology, abnormal intestinal epithelium morphology, abnormal keratinocyte morphology, abnormal kidney development, abnormal kidney morphology, abnormal lateral nasal prominence morphology, abnormal lens capsule morphology, abnormal lens development, abnormal lens epithelium morphology, abnormal ligament morphology, abnormal limb development, abnormal long bone epiphyseal plate morphology, abnormal long term object recognition memory, abnormal lung development, abnormal lung vasculature morphology, abnormal mandibular prominence morphology, abnormal maxillary prominence morphology, abnormal maxillary shelf morphology, abnormal maxillary zygomatic process morphology, abnormal medial nasal prominence morphology, abnormal melanoblast morphology, abnormal melanogenesis, abnormal mesoderm development, abnormal muscle development, abnormal nasal capsule morphology, abnormal nasal placode morphology, abnormal nest building behavior, abnormal neurocranium morphology, abnormal neuron differentiation, abnormal neuron physiology, abnormal nursing, abnormal operant conditioning behavior, abnormal optic eminence morphology, abnormal oral cavity morphology, abnormal osteoblast differentiation, abnormal osteoclast differentiation, abnormal perichondrium morphology, abnormal pinna hair pigmentation, abnormal placenta morphology, abnormal placental labyrinth vasculature morphology, abnormal proximal-distal axis patterning, abnormal response to social novelty, abnormal retina vasculature morphology, abnormal rostral-caudal axis patterning, abnormal seminiferous tubule morphology, abnormal small intestinal crypt cell proliferation, abnormal somite development, abnormal spatial reference memory, abnormal spermatogonia morphology, abnormal spinal cord medial motor column morphology, abnormal startle reflex, abnormal suckling behavior, abnormal synaptic vesicle clustering, abnormal tail hair pigmentation, abnormal telencephalon development, abnormal telencephalon morphology, abnormal tooth development, abnormal trigeminal V mesencephalic nucleus morphology, abnormal tympanic ring morphology, abnormal umbilical cord blood vessel morphology, abnormal urinary bladder urothelium morphology, abnormal vagus nerve morphology, abnormal vascular endothelial cell morphology, abnormal vascular regression, abnormal vasculogenesis, abnormal visceral yolk sac morphology, abnormal vitelline vasculature morphology, abnormal vocalization, absent allantois, absent amniotic folds, absent cerebellum, absent choroid plexus, absent coat pigmentation, absent craniofacial bones, absent deltoid tuberosity, absent dentate gyrus, absent hair follicles, absent hindlimb, absent hippocampal commissure, absent hippocampus CA1 region, absent hippocampus CA2 region, absent hippocampus CA3 region, absent hyoid bone, absent lactotrophs, absent lower incisors, absent lung buds, absent lungs, absent mandible, absent maxilla, absent mesoderm, absent metencephalon, absent midbrain-hindbrain boundary, absent nephrogenic zone, absent oculomotor nerve, absent somatotrophs, absent thyrotrophs, absent vibrissae, accelerated hair follicle regression, arrested osteoblast differentiation, behavior/neurological phenotype, broad head, cardiovascular system phenotype, caudal body truncation, decreased Paneth cell number, decreased body size, decreased bone marrow cell number, decreased bone mass, decreased bone mineralization, decreased brain size, decreased cell proliferation, decreased corpus callosum size, decreased diameter of humerus, decreased embryo size, decreased gamma-delta T cell number, decreased gonadotroph cell number, decreased hair follicle number, decreased kidney cell proliferation, decreased kidney collecting duct number, decreased melanoblast proliferation, decreased motor neuron number, decreased osteoclast cell number, decreased pancreas weight, decreased prepulse inhibition, decreased response of heart to induced stress, decreased spinal cord size, decreased testis weight, decreased trabecular bone volume, delayed intramembranous bone ossification, dilated renal tubules, diluted coat color, disorganized secondary lens fibers, domed cranium, ectopic Paneth cells, ectopic cartilage, ectopic limbs, embryo phenotype, embryonic growth retardation, embryonic lethality between implantation and somite formation, complete penetrance, embryonic lethality during organogenesis, complete penetrance, embryonic lethality during organogenesis, incomplete penetrance, embryonic lethality, complete penetrance, enhanced spatial learning, enlarged thalamus, failure of Mullerian duct regression, failure of bone ossification, failure to gastrulate, flattened snout, focal hair loss, forebrain hypoplasia, fused synovial joints, fusion of basioccipital and basisphenoid bone, growth retardation of incisors, growth retardation of molars, hair follicle degeneration, impaired branching involved in ureteric bud morphogenesis, impaired contextual conditioning behavior, increased anxiety-related response, increased bone mass, increased bone mineral content, increased bone volume, increased brain size, increased chondrocyte apoptosis, increased corticotroph cell number, increased ectoderm apoptosis, increased gastrointestinal tumor incidence, increased granulosa cell tumor incidence, increased grooming behavior, increased hair follicle apoptosis, increased intestinal adenoma incidence, increased lens epithelium apoptosis, increased mammary gland tumor incidence in breeding females, increased metanephric mesenchyme apoptosis, increased neutrophil cell number, increased osteoclast cell number, increased osteoma incidence, increased pituitary gland tumor incidence, increased prostate gland adenocarcinoma incidence, increased prostate intraepithelial neoplasia incidence, increased spinal cord size, increased startle reflex, increased striatum size, increased susceptibility to pharmacologically induced seizures, increased testis tumor incidence, increased thigmotaxis, increased tumor incidence, increased urinary bladder carcinoma incidence, integument phenotype, lethality at weaning, complete penetrance, lethality throughout fetal growth and development, incomplete penetrance, loss of vibrissae, narrow frontonasal prominence, neonatal lethality, complete penetrance, no abnormal phenotype detected, pale yolk sac, pancreatic acinar hypoplasia, pericardial edema, perinatal lethality, complete penetrance, postnatal lethality, complete penetrance, premature death, premature endochondral bone ossification, premature neuronal precursor differentiation, prenatal lethality, prenatal lethality, complete penetrance, prenatal lethality, incomplete penetrance, preweaning lethality, complete penetrance, preweaning lethality, incomplete penetrance, reduced hair shaft melanin granule number, reduced long term potentiation, ruptured lens capsule, seminiferous tubule degeneration, skeleton phenotype, skin fibrosis, skin lesions, slow extinction of fear memory, small adenohypophysis, small cerebellum, small heart, small kidney, small olfactory bulb, small pharyngeal arch, spinal hemorrhage, squamous metaplasia of bulbourethral gland, squamous metaplasia of preputial gland, squamous metaplasia of urethral gland, thick epidermis stratum basale, thick epidermis suprabasal layer, thin placenta labyrinth, ureter hypoplasia