mcl1 Phenotypes

Summary

Expression

Phenotypes

XB-GENEPAGE-487619

Gene Symbol: mcl1 Gene Name: MCL1, BCL2 family apoptosis regulator

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Computed annotations: mcl1 assayed (1 source)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Mouse (40 sources): abnormal CD8-positive, alpha-beta T cell physiology, abnormal T cell differentiation, abnormal double-positive T cell morphology, abnormal embryo attachment, abnormal mean corpuscular volume, abnormal visceral yolk sac morphology, absent early pro-B cells, absent germinal center B cells, absent late pro-B cells, absent memory B cells, absent pre-B cells, arrested B cell differentiation, arrested T cell differentiation, decreased CD4-positive, alpha beta T cell number, decreased IgG1 level, decreased double-negative T cell number, decreased double-positive T cell number, decreased erythrocyte cell number, decreased germinal center B cell number, decreased granulocyte number, decreased hematocrit, decreased mast cell number, decreased memory B cell number, decreased naive B cell number, decreased single-positive T cell number, decreased susceptibility to type I hypersensitivity reaction, decreased thymocyte number, embryo phenotype, embryonic growth arrest, embryonic lethality at implantation, complete penetrance, embryonic lethality before implantation, incomplete penetrance, failure of blastocyst to hatch from the zona pellucida, hematopoietic system phenotype, immune system phenotype, impaired neutrophil recruitment, increased B cell apoptosis, increased T cell apoptosis, increased double-positive T cell number, no abnormal phenotype detected, preweaning lethality, complete penetrance [+]

Monarch Ortholog Phenotypes

These phenotypes are associated with this gene with a has phenotype relation via Monarch.

Mouse (40 sources): abnormal CD8-positive, alpha-beta T cell physiology, abnormal T cell differentiation, abnormal double-positive T cell morphology, abnormal embryo attachment, abnormal mean corpuscular volume, abnormal visceral yolk sac morphology, absent early pro-B cells, absent germinal center B cells, absent late pro-B cells, absent memory B cells, [+]