cdkn1a Phenotypes

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Phenotypes

Gene Literature (210)

Nucleotides (112)

Interactants (828)

XB-GENEPAGE-487801

Gene Symbol: cdkn1a Gene Name: cyclin-dependent kinase inhibitor 1A

Anatomical Phenotypes Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.
abnormal pronephric kidney (1 source), abnormal pronephric tubule morphology (1 source), decreased size of the distal tubule (1 source), decreased size of the proximal tubule (1 source)

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: cdkn1a assayed (2 sources)
Computed annotations: cdkn1a assayed (16 sources)

Experiments (Reagents) These are short form descriptions of experiments using reagents targeting the gene of interest.
Xla Wt + cdkn1a (cip1) (1 source)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (1 source): Ischemic stroke
Mouse (82 sources): abnormal CD4-positive, alpha beta T cell morphology, abnormal DNA replication, abnormal auchene hair morphology, abnormal awl hair morphology, abnormal bone marrow cell morphology/development, abnormal cell cycle checkpoint function, abnormal chromosome number, abnormal epididymis morphology, abnormal hematopoietic stem cell physiology, abnormal junctional epithelium morphology, abnormal keratinocyte physiology, abnormal neuronal precursor proliferation, abnormal oval cell morphology, abnormal prostate gland dorsolateral lobe morphology, abnormal response to CNS ischemic injury, abnormal self tolerance, abnormal seminal vesicle morphology, abnormal thymus physiology, abnormal tumor incidence, cardiovascular system phenotype, decreased body size, decreased hepatocyte proliferation, decreased incidence of tumors by ionizing radiation induction, decreased lymphoma incidence, decreased mortality induced by ionizing radiation, decreased physiological sensitivity to xenobiotic, decreased prostate gland weight, decreased seminal vesicle weight, decreased sensitivity to skin irradiation, decreased susceptibility to induced arthritis, decreased zigzag hair amount, delayed cellular replicative senescence, enlarged cervical lymph nodes, enlarged epididymis, enlarged heart atrium, enlarged lymph nodes, growth/size/body region phenotype, hearing/vestibular/ear phenotype, homeostasis/metabolism phenotype, immune system phenotype, impaired macrophage chemotaxis, increased B cell derived lymphoma incidence, increased IgG1 level, increased Leydig cell tumor incidence, increased T cell derived lymphoma incidence, increased T cell proliferation, increased anti-double stranded DNA antibody level, increased anti-histone antibody level, increased anti-nuclear antigen antibody level, increased anti-single stranded DNA antibody level, increased autoantibody level, increased brain weight, increased brown adipose tissue amount, increased cell proliferation, increased cellular sensitivity to gamma-irradiation, increased cellular sensitivity to ultraviolet irradiation, increased fibroblast proliferation, increased hematopoietic stem cell number, increased hepatocellular carcinoma incidence, increased histiocytic sarcoma incidence, increased incidence of tumors by chemical induction, increased incidence of tumors by ionizing radiation induction, increased inguinal fat pad weight, increased kidney weight, increased lung carcinoma incidence, increased malignant tumor incidence, increased memory T cell number, increased metastatic potential, increased neuron number, increased neuronal precursor cell number, increased parametrial fat pad weight, increased sensitivity to induced cell death, increased sensitivity to induced morbidity/mortality, increased sensitivity to xenobiotic induced morbidity/mortality, increased skin tumor incidence, increased spleen weight, increased tumor incidence, increased urinary system tumor incidence, increased white fat cell number, premature death, small seminal vesicle, spleen hyperplasia [+]
View all ortholog results at Monarch