hes1 Phenotypes

Summary

Expression

Phenotypes

XB-GENEPAGE-487994

Gene Symbol: hes1 Gene Name: hes family bHLH transcription factor 1

Anatomical Phenotypes Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.
abnormal cell migration in neural crest (2 sources), abnormally decreased number of apoptotic cell (1 source), abnormally increased number of apoptotic cell (1 source)

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: hes1 manipulated (12 sources), hes1 assayed (2 sources)
Computed annotations: hes1 assayed (3 sources)

Experiments (Reagents) These are short form descriptions of experiments using reagents targeting the gene of interest.
Xla Wt + dnhes1-GR + DEX (3 sources), Xla Wt + hes1-GR + DEX (3 sources), Xla Wt + dnhes1-GR + DEX (2 sources), Xla Wt + dnhes1-GR + DEX + aphidicolin + hydroxyurea (2 sources), Xla Wt + hes1-GR + DEX (2 sources), Xla Wt + hes1-GR + DEX + aphidicolin + hydroxyurea (2 sources)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Mouse (47 sources): abnormal bile duct development, abnormal bile duct morphology, abnormal brain development, abnormal cell differentiation, abnormal cochlear hair cell morphology, abnormal cystic duct morphology, abnormal exocrine pancreas morphology, abnormal extrahepatic bile duct morphology, abnormal nasal placode morphology, abnormal neuron differentiation, abnormal pancreas development, abnormal pancreatic beta cell differentiation, abnormal pituitary gland development, abnormal retina neuronal layer morphology, abnormal T cell differentiation, decreased body length, decreased club cell number, decreased DN1 thymic pro-T cell number, decreased DN2 thymocyte number, decreased DN3 thymocyte number, decreased DN4 thymocyte number, decreased double-positive T cell number, decreased embryo size, decreased gamma-delta T cell number, decreased melanoblast apoptosis, disorganized retina layers, embryonic lethality during organogenesis, complete penetrance, embryonic lethality during organogenesis, incomplete penetrance, everted embryonic neuroepithelium, hematopoietic system phenotype, immune system phenotype, incomplete rostral neuropore closure, increased cochlear inner hair cell number, increased cochlear outer hair cell number, increased DN1 thymic pro-T cell number, increased immature B cell number, increased number of pulmonary neuroendocrine bodies, increased solitary pulmonary neuroendocrine cell number, increased vestibular hair cell number, kinked neural tube, lethality throughout fetal growth and development, incomplete penetrance, nervous system phenotype, no abnormal phenotype detected, perinatal lethality, complete penetrance, pigmentation phenotype, small lung, small stomach [+]

Monarch Ortholog Phenotypes

These phenotypes are associated with this gene with a has phenotype relation via Monarch.

Mouse (47 sources): abnormal bile duct development, abnormal bile duct morphology, abnormal brain development, abnormal cell differentiation, abnormal cochlear hair cell morphology, abnormal cystic duct morphology, abnormal exocrine pancreas morphology, abnormal extrahepatic bile duct morphology, abnormal nasal placode morphology, abnormal neuron differentiation, [+]