| Monarch Ortholog Phenotypes
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Human (30 sources):
Abdominal distention,
Abnormality of the face,
Abnormality of the hypothalamus-pituitary axis,
Adrenocorticotropic hormone deficiency,
Anterior hypopituitarism,
Anterior pituitary hypoplasia,
Central hypothyroidism,
Coarse facial features,
Constipation,
Decreased response to growth hormone stimulation test,
Fatigue,
Feeding difficulties,
Global developmental delay,
Gonadotropin deficiency,
Hypothalamic luteinizing hormone-releasing hormone deficiency,
Hypothyroidism,
Hypotonia,
Intellectual disability,
Jaundice,
Large fontanelles,
Orofacial cleft,
Pituitary dwarfism,
Pituitary hypothyroidism,
Sensorineural hearing impairment,
Septo-optic dysplasia,
Short neck,
Short stature,
Sleep abnormality,
Thoracolumbar kyphoscoliosis,
Umbilical hernia
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Mouse (43 sources):
abnormal Rathke's pouch apoptosis,
abnormal Rathke's pouch development,
abnormal corticotroph morphology,
abnormal craniofacial morphology,
abnormal fertility/fecundity,
abnormal pituitary gland development,
abnormal pituitary hormone level,
abnormal sex gland secretion,
abnormal thyroid follicle morphology,
abnormal uterus development,
abnormal uterus morphology,
absent adenohypophysis,
absent lactotrophs,
absent pituitary intermediate lobe,
absent somatotrophs,
absent thyrotrophs,
adrenal cortical hyperplasia,
decreased adrenocorticotropin level,
decreased body size,
decreased circulating insulin-like growth factor I level,
decreased circulating prolactin level,
decreased circulating thyroxine level,
decreased follicle stimulating hormone level,
decreased gonadotroph cell number,
decreased growth hormone level,
decreased lactotroph cell number,
decreased luteinizing hormone level,
decreased prolactin level,
decreased survivor rate,
decreased thyroid-stimulating hormone level,
decreased uterus weight,
endocrine/exocrine gland phenotype,
hearing/vestibular/ear phenotype,
nervous system phenotype,
perinatal lethality, incomplete penetrance,
premature death,
prenatal lethality, complete penetrance,
reduced male fertility,
reproductive system phenotype,
small pituitary intermediate lobe,
small prostate gland,
small seminal vesicle,
small uterus
[+]
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View all ortholog results at Monarch
|
Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.