rab27a Phenotypes

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Phenotypes

Gene Literature (3)

Nucleotides (200)

Interactants (62)

XB-GENEPAGE-490562

Gene Symbol: rab27a Gene Name: RAB27A, member RAS oncogene family

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Computed annotations: rab27a assayed (1 source)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (27 sources): Abnormal cerebellum morphology, Accumulation of melanosomes in melanocytes, Fever, Hemophagocytosis, Hepatomegaly, Hyperlipidemia, Hypopigmentation of hair, Hypopigmentation of the skin, Immunodeficiency, Iris hypopigmentation, Jaundice, Lymphadenopathy, Melanin pigment aggregation in hair shafts, Nausea and vomiting, Neutropenia, Pancytopenia, Partial albinism, Petechiae, Premature graying of hair, Progressive neurologic deterioration, Pulmonary infiltrates, Recurrent bacterial infections, Reduced delayed hypersensitivity, Seizure, Silver-gray hair, Spasticity, Splenomegaly [+]
Mouse (29 sources): abnormal Harderian gland pigmentation, abnormal NK cell degranulation, abnormal cytotoxic T cell physiology, abnormal melanocyte morphology, abnormal melanosome transport, abnormal platelet dense granule morphology, abnormal platelet dense granule physiology, abnormal vesicle-mediated transport, cellular phenotype, decreased NK cell degranulation, decreased cytotoxic T cell cytolysis, decreased erythrocyte cell number, decreased platelet ADP level, decreased platelet ATP level, decreased platelet dense granule number, decreased platelet serotonin level, diluted coat color, hunched posture, immune system phenotype, impaired natural killer cell mediated cytotoxicity, increased circulating aspartate transaminase level, increased circulating interferon-gamma level, increased circulating interleukin-1 beta level, increased circulating interleukin-6 level, increased circulating lactate dehydrogenase level, increased circulating tumor necrosis factor level, increased susceptibility to Riboviria infection, integument phenotype, vision/eye phenotype [+]
View all ortholog results at Monarch