rbpj Phenotypes

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Phenotypes

Gene Literature (38)

Nucleotides (115)

Interactants (279)

XB-GENEPAGE-490755

Gene Symbol: rbpj Gene Name: recombination signal binding protein for immunoglobulin kappa J region

Anatomical Phenotypes Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.
abnormal development of hypochord (1 source)

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: rbpj manipulated (13 sources)
Computed annotations: rbpj manipulated (6 sources), rbpj assayed (4 sources)

Experiments (Reagents) These are short form descriptions of experiments using reagents targeting the gene of interest.
Xla Wt + dnrbpj (8 sources), Xla Wt + DNrbpj + DNmcidas - animal cap explant (3 sources), Xla Wt + DNrbpj - animal cap explant (3 sources), Xla Wt + carbpj-notch1del-GR (3 sources), Xla Wt + ptf1a + rbpj (1 source), Xla Wt + dnrbpj (1 source), Xla Wt + dnrbpj (1 source)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (53 sources): 2-3 toe syndactyly, Abnormal pulmonary valve morphology, Abnormality of the lower limb, Abnormality of the metacarpal bones, Abnormality of the upper limb, Absent fingernail, Absent hand, Aplasia cutis congenita, Aplasia of the fingers, Aplasia/Hypoplasia of the skin, Aplastic/hypoplastic toenail, Arteriovenous malformation, Ascites, Blepharophimosis, Brachydactyly, Calvarial skull defect, Cataract, Cirrhosis, Congenital hepatic fibrosis, Cutis marmorata, EEG abnormality, Encephalocele, Esophageal varix, Failure to thrive, Finger syndactyly, Gastrointestinal hemorrhage, Global developmental delay, Hemiparesis, Hydrocephalus, Hypoplastic fingernail, Intellectual disability, Leukopenia, Microcephaly, Microphthalmia, Periventricular leukomalacia, Porencephalic cyst, Portal hypertension, Premature birth, Psychomotor retardation, Pulmonary arterial hypertension, Pulmonary artery atresia, Seizure, Short distal phalanx of finger, Short metatarsal, Short palpebral fissure, Sparse hair, Spasticity, Split hand, Strabismus, Talipes equinovarus, Tetralogy of Fallot, Thrombocytopenia, obsolete Hypotrichosis [+]
Mouse (105 sources): abnormal CD4-positive helper T cell morphology, abnormal T-helper 2 cell differentiation, abnormal anterior cardinal vein morphology, abnormal aortic valve morphology, abnormal atrioventricular cushion morphology, abnormal bone mineralization, abnormal cardiac epithelial to mesenchymal transition, abnormal cell differentiation, abnormal common cardinal vein morphology, abnormal crypts of Lieberkuhn morphology, abnormal diaphragm morphology, abnormal digestion, abnormal dorsal aorta morphology, abnormal epaxial muscle morphology, abnormal fetal cardiomyocyte proliferation, abnormal glutaminergic neuron morphology, abnormal hair follicle melanocyte morphology, abnormal hair follicle melanogenesis, abnormal heart development, abnormal heart echocardiography feature, abnormal humoral immune response, abnormal intercostal muscle morphology, abnormal intestinal epithelium morphology, abnormal intestinal goblet cell morphology, abnormal locomotor behavior, abnormal lymphopoiesis, abnormal mammary gland growth during pregnancy, abnormal melanoblast morphology, abnormal myocardium layer morphology, abnormal myogenesis, abnormal neuron differentiation, abnormal pancreas development, abnormal pancreatic alpha cell differentiation, abnormal placental labyrinth vasculature morphology, abnormal proximal convoluted tubule morphology, abnormal regulatory T cell physiology, abnormal response to infection, abnormal spinal cord interneuron morphology, abnormal suckling behavior, abnormal vascular regression, abnormal vitelline vascular remodeling, absent club cells, absent coat pigmentation, absent podocytes, absent vitelline blood vessels, aortic valve inflammation, arrested T cell differentiation, cardiac fibrosis, decreased bone mineral content, decreased cardiac muscle contractility, decreased dendritic cell number, decreased double-positive T cell number, decreased follicular dendritic cell number, decreased interleukin-4 secretion, decreased locomotor activity, decreased marginal zone B cell number, decreased melanocyte number, decreased neuronal precursor cell number, decreased pancreatic acinar cell number, decreased pancreatic islet number, decreased satellite cell number, decreased single-positive T cell number, decreased skeletal muscle fiber density, decreased spongiotrophoblast size, decreased thymocyte number, decreased tumor growth/size, diluted coat color, disorganized myocardium, disorganized pancreatic islets, embryonic growth retardation, embryonic lethality between somite formation and embryo turning, complete penetrance, embryonic lethality during organogenesis, complete penetrance, embryonic lethality prior to tooth bud stage, embryonic lethality, incomplete penetrance, epidermal cyst, heart inflammation, hypaxial muscle hypoplasia, immune system phenotype, increased IgG3 level, increased T cell proliferation, increased double-negative T cell number, increased follicular B cell number, increased grip strength, increased macrophage cell number, increased pancreatic alpha cell number, increased plasmacytoid dendritic cell number, increased single-positive T cell number, increased splenocyte number, increased susceptibility to bacterial infection induced morbidity/mortality, increased thigmotaxis, loss of GABAergic neurons, loss of vibrissae, neonatal lethality, complete penetrance, no abnormal phenotype detected, no spontaneous movement, pigmentation phenotype, postnatal lethality, complete penetrance, premature hair loss, prenatal lethality, complete penetrance, preweaning lethality, complete penetrance, skeleton phenotype, small pancreas, small thymus, thick aortic valve cusps, trabecula carnea hypoplasia [+]
View all ortholog results at Monarch