| Monarch Ortholog Phenotypes
|
Human (23 sources):
Abnormal respiratory system physiology,
Agitation,
Amyotrophic lateral sclerosis,
Anxiety,
Degeneration of anterior horn cells,
Depression,
Dyspnea,
Emotional lability,
Fatigable weakness of bulbar muscles,
Fatigable weakness of respiratory muscles,
Fatigable weakness of swallowing muscles,
Fatigue,
Generalized muscle weakness,
Laryngospasm,
Muscle spasm,
Nausea and vomiting,
Neurodegeneration,
Pain,
Paralysis,
Respiratory insufficiency,
Skeletal muscle atrophy,
Spasticity,
Xerostomia
[+]
|
|
Mouse (4 sources):
abnormal macrophage chemotaxis,
abnormal macrophage physiology,
increased susceptibility to atherosclerosis,
oxidative stress
|
View all ortholog results at Monarch
|
Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.