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Summary Expression Phenotypes Gene Literature (12) GO Terms (5) Nucleotides (296) Proteins (36) Interactants (154) Wiki

dsp     desmoplakin

Anatomical Phenotypes
Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.
abnormal epidermis morphology (19 sources), decreased size of the embryo (9 sources), abnormal eye morphology (5 sources), abnormal craniofacial region morphology (4 sources), abnormal tail morphology (4 sources), obsolete abnormally edematous heart (4 sources), abnormal development of multiciliated cell (3 sources), abnormally decreased number of multiciliated epidermal cell (3 sources), increased pigmentation in the epidermis (3 sources), abnormal incomplete closing of the neural fold (2 sources), abnormally localised multiciliated cell (2 sources), decreased size of the multiciliated cell (2 sources), abnormal development of eye (1 source), abnormal development of fin (1 source), abnormal development of mouth (1 source), abnormal development of small secretory cell (1 source), abnormal epidermis inner layer morphology (1 source), abnormal epidermis outer layer morphology (1 source), abnormal fin morphology (1 source), abnormal mouth morphology (1 source), abnormally decreased number of small secretory cell (1 source), abnormally localised microtubule (1 source), decreased size of the apical region (1 source)
Expression Phenotypes
Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: dsp manipulated (7 sources)
Computed annotations: dsp assayed (5 sources)
Diseases from the human disease ontology (DO) manually associated with phenotypes from disease models. Sources are grouped by anatomical (AP) and expression (EP) phenotypes.
skin disease (24AP sources, 7 EP sources)
Experiments (Reagents)
These are short form descriptions of experiments using reagents targeting the gene of interest.
Xla Wt + dsp MO (12 sources), Xla Wt + dsp MO (4 sources), Xla Wt + dsp CRISPR1 (3 sources), Xla Wt + dsp CRISPR2 (3 sources), Xla Wt + dsp MO (3 sources), Xla Wt + Hsa.DSPdel (3 sources), Xla Wt + dsp MO (2 sources), Xla Wt + dsp MO + Impact Assay (1 source), Xla Wt + dsp MO + Rotation Assay (1 source)
Monarch Ortholog Phenotypes
These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (63 sources): Abnormal hair morphology, Abnormality of the cardiovascular system, Abnormality of the nail, Acantholysis, Alopecia universalis, Anonychia, Aplasia cutis congenita, Cardiomegaly, Cardiomyocyte hypertrophy, Cardiomyopathy, [+]
Mouse (47 sources): abnormal R wave, abnormal T wave, abnormal Z line morphology, abnormal cell adhesion, abnormal corneocyte envelope morphology, abnormal ectoderm development, abnormal egg cylinder morphology, abnormal embryo turning, abnormal embryonic tissue morphology, abnormal endoderm development, [+]

View all ortholog results at Monarch