ldb1 Phenotypes

Summary

Expression

Phenotypes

XB-GENEPAGE-493238

Gene Symbol: ldb1 Gene Name: LIM domain binding 1

Anatomical Phenotypes Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.
duplicated main body axis (5 sources), duplicated head (4 sources), absent head (2 sources), duplicated eye (2 sources)

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: ldb1 manipulated (1 source)

Experiments (Reagents) These are short form descriptions of experiments using reagents targeting the gene of interest.
Xla Wt + tle1 + gsc + otx2 + ssbp3 + ldb1 + lhx1 mRNA (3 sources), Xla Wt + otx2 + ssbp3 + ldb1 + lhx1 (1 source), Xla Wt + otx2 + ssbp3 + ldb1 + lhx1 mRNA (1 source), Xtr Wt + ssbp3 + ldb1 + lhx1 mRNA (1 source)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Mouse (43 sources): abnormal allantois morphology, abnormal craniofacial morphology, abnormal embryonic erythropoiesis, abnormal extraembryonic tissue morphology, abnormal foregut morphology, abnormal glomerular capillary endothelium morphology, abnormal hematopoietic system morphology/development, abnormal neural plate morphology, abnormal podocyte foot process morphology, abnormal primitive streak formation, abnormal primitive streak morphology, abnormal primordial germ cell morphology, abnormal renal glomerulus basement membrane morphology, abnormal rhombomere 3 morphology, abnormal rhombomere 5 morphology, abnormal vascular development, abnormal visceral yolk sac morphology, absent allantois, absent cerebellar foliation, absent glomerular endothelium fenestra, absent heart, absent midbrain-hindbrain boundary, absent visceral yolk sac blood islands, decreased Purkinje cell number, decreased embryo size, dilated renal tubules, embryonic growth arrest, embryonic lethality, complete penetrance, embryonic-extraembryonic boundary constriction, failure of chorioallantoic fusion, fused somites, increased somite number, kinked neural tube, no abnormal phenotype detected, podocyte foot process effacement, premature death, renal cast, renal glomerular synechia, renal glomerulus atrophy, rostral body truncation, rostral-caudal axis duplication, small cerebellum, split notochord [+]

Monarch Ortholog Phenotypes

These phenotypes are associated with this gene with a has phenotype relation via Monarch.

Mouse (43 sources): abnormal allantois morphology, abnormal craniofacial morphology, abnormal embryonic erythropoiesis, abnormal extraembryonic tissue morphology, abnormal foregut morphology, abnormal glomerular capillary endothelium morphology, abnormal hematopoietic system morphology/development, abnormal neural plate morphology, abnormal podocyte foot process morphology, abnormal primitive streak formation, [+]