ifnar1 Phenotypes

Summary

Expression

Phenotypes

Gene Literature (1)

XB-GENEPAGE-493477

Gene Symbol: ifnar1 Gene Name: interferon alpha and beta receptor subunit 1

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Computed annotations: ifnar1 assayed (2 sources)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Mouse (54 sources): abnormal CD8-positive, alpha-beta T cell physiology, abnormal cytokine level, abnormal dendritic cell physiology, abnormal interferon-gamma secretion, abnormal lean body mass, abnormal macrophage physiology, abnormal mononuclear phagocyte morphology, abnormal osteoclast morphology, abnormal response to infection, abnormal susceptibility to infection, abnormal vibrissa morphology, decreased IgG1 level, decreased IgG2a level, decreased IgG3 level, decreased KLRG1-positive NK cell number, decreased Ly6C high monocyte number, decreased T cell apoptosis, decreased circulating fructosamine level, decreased interferon-alpha secretion, decreased interferon-beta secretion, decreased interleukin-6 secretion, decreased susceptibility to Coronaviridae infection, decreased tumor necrosis factor secretion, immune system phenotype, impaired natural killer cell mediated cytotoxicity, improved glucose tolerance, increased CD4-positive, alpha beta T cell number, increased CD8-positive, alpha-beta T cell number, increased bone mineral content, increased circulating alanine transaminase level, increased circulating creatinine level, increased circulating interleukin-12 level, increased incidence of induced tumors, increased incidence of tumors by chemical induction, increased lean body mass, increased susceptibility to Adenoviridae infection, increased susceptibility to Coronaviridae infection, increased susceptibility to Coronaviridae infection induced morbidity/mortality, increased susceptibility to Herpesvirales infection, increased susceptibility to Herpesvirales infection induced morbidity/mortality, increased susceptibility to Orthomyxoviridae infection, increased susceptibility to Orthomyxoviridae infection induced morbidity/mortality, increased susceptibility to Paramyxoviridae infection, increased susceptibility to Paramyxoviridae infection induced morbidity/mortality, increased susceptibility to Picornaviridae infection, increased susceptibility to Picornaviridae infection induced morbidity/mortality, increased susceptibility to Poxviridae infection, increased susceptibility to Riboviria infection, increased susceptibility to Togaviridae infection, increased susceptibility to Togaviridae infection induced morbidity/mortality, increased susceptibility to bacterial infection induced morbidity/mortality, increased tumor growth/size, induced hyperactivity, liver hemorrhage [+]

Monarch Ortholog Phenotypes

These phenotypes are associated with this gene with a has phenotype relation via Monarch.

Mouse (54 sources): abnormal CD8-positive, alpha-beta T cell physiology, abnormal cytokine level, abnormal dendritic cell physiology, abnormal interferon-gamma secretion, abnormal lean body mass, abnormal macrophage physiology, abnormal mononuclear phagocyte morphology, abnormal osteoclast morphology, abnormal response to infection, abnormal susceptibility to infection, [+]