| Monarch Ortholog Phenotypes
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Human (18 sources):
Agenesis of corpus callosum,
Babinski sign,
CNS demyelination,
Cerebellar atrophy,
Dysarthria,
Dysmetria,
Gait ataxia,
Hyperreflexia,
Impaired distal vibration sensation,
Impaired proprioception,
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Mouse (21 sources):
abnormal anxiety-related response,
abnormal brain interneuron morphology,
abnormal cerebellar granule cell morphology,
abnormal response to tactile stimuli,
abnormal response/metabolism to endogenous compounds,
abnormal thermal nociception,
abnormal touch/ nociception,
decreased abdominal adipose tissue amount,
decreased anxiety-related response,
decreased chemically-elicited antinociception,
decreased circulating glucose level,
decreased circulating insulin-like growth factor I level,
decreased circulating thyroxine level,
decreased lean body mass,
decreased locomotor activity,
decreased respiratory quotient,
decreased white adipose tissue amount,
impaired conditioned place preference behavior,
increased bone mineral content,
increased defecation amount,
increased susceptibility to pharmacologically induced seizures
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View all ortholog results at Monarch
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Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.