| Monarch Ortholog Phenotypes
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Human (20 sources):
Abnormality of the dentition,
Biconcave vertebral bodies,
Blue sclerae,
Bowing of the long bones,
Broad forehead,
Delayed speech and language development,
Femoral bowing,
Generalized osteoporosis,
Joint hypermobility,
Long eyelashes,
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Mouse (34 sources):
abnormal cranium morphology,
abnormal deltoid tuberosity morphology,
abnormal exploration in a new environment,
abnormal humerus morphology,
abnormal ischium morphology,
abnormal kidney weight,
abnormal limb morphology,
abnormal mandible morphology,
abnormal spine curvature,
abnormal thoracic cage shape,
abnormal thymus morphology,
abnormal vertebral column morphology,
absent bone trabeculae,
decreased Ly6C-positive mature NK cell number,
decreased body size,
decreased cardiac output,
decreased cardiac stroke volume,
decreased exploration in new environment,
decreased femur compact bone thickness,
decreased kidney weight,
delayed bone ossification,
immune system phenotype,
impaired righting response,
increased Ly6C-positive immature NK cell number,
increased alkaline phosphatase activity,
increased diameter of femur,
increased diameter of humerus,
increased long bone epiphyseal plate size,
lethality, incomplete penetrance,
skeleton phenotype,
small cranium,
small ischium,
thin neurocranium,
transmission ratio distortion
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View all ortholog results at Monarch
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Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.