ptk7 Phenotypes

Phenotypes

XB-GENEPAGE-5846943

Gene Symbol: ptk7 Gene Name: protein tyrosine kinase 7 (inactive)

Anatomical Phenotypes Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.
abnormal incomplete closing of the blastopore (1 source), abnormal incomplete closing of the neural tube (1 source), decreased length of anterior-posterior axis (1 source), increased width of neural plate (1 source)

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: ptk7 manipulated (5 sources), ptk7 assayed (1 source)

Experiments (Reagents) These are short form descriptions of experiments using reagents targeting the gene of interest.
Xla Wt + ptk7 MO (4 sources), Xla Wt + ptk7del_1-2178-GFP (1 source), Xla Wt + ptk7del_1-2178-GFP + animal cap explant (1 source), Xla Wt + ptk7del_1-2178-GFP + animal cap explant (1 source)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Mouse (26 sources): abnormal cochlear inner hair cell morphology, abnormal embryo development, abnormal glossopharyngeal ganglion morphology, abnormal lung lobe morphology, abnormal neural crest cell morphology, abnormal orientation of inner hair cell stereociliary bundles, abnormal orientation of outer hair cell stereociliary bundles, abnormal outer hair cell kinocilium location or orientation, abnormal response to new environment, abnormal somite shape, abnormal thoracic vertebrae morphology, abnormal vagus ganglion morphology, absent tail, decreased locomotor activity, decreased spinal cord size, enlarged floor plate, enlarged trigeminal ganglion, incomplete embryo turning, increased cochlear inner hair cell number, increased cochlear outer hair cell number, kinked neural tube, perinatal lethality, complete penetrance, preweaning lethality, complete penetrance, small kidney, small lung lobe, thick lung-associated mesenchyme [+]

Monarch Ortholog Phenotypes

These phenotypes are associated with this gene with a has phenotype relation via Monarch.

Mouse (26 sources): abnormal cochlear inner hair cell morphology, abnormal embryo development, abnormal glossopharyngeal ganglion morphology, abnormal lung lobe morphology, abnormal neural crest cell morphology, abnormal orientation of inner hair cell stereociliary bundles, abnormal orientation of outer hair cell stereociliary bundles, abnormal outer hair cell kinocilium location or orientation, abnormal response to new environment, abnormal somite shape, [+]