Monarch Ortholog Phenotypes
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Mouse (21 sources):
abnormal gut flora balance,
abnormal large intestine crypts of Lieberkuhn morphology,
abnormal macrophage physiology,
abnormal response to infection,
decreased circulating interleukin-1 beta level,
decreased circulating interleukin-18 level,
decreased incidence of tumors by chemical induction,
decreased interferon-gamma secretion,
decreased interleukin-1 alpha secretion,
decreased interleukin-1 beta secretion,
decreased interleukin-18 secretion,
decreased interleukin-6 secretion,
decreased susceptibility to endotoxin shock,
decreased susceptibility to type IV hypersensitivity reaction,
decreased tumor necrosis factor secretion,
enlarged Peyer's patches,
increased IgG2c level,
increased interferon-beta secretion,
increased susceptibility to Herpesvirales infection,
increased susceptibility to induced colitis,
increased tumor necrosis factor secretion
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