| Monarch Ortholog Phenotypes
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Human (51 sources):
Abnormal CD4:CD8 ratio,
Abnormal facial shape,
Abnormality of humoral immunity,
Acute otitis media,
Agammaglobulinemia,
Autoimmune hemolytic anemia,
Autoimmune thrombocytopenia,
Autoimmunity,
Biliary tract abnormality,
Cholangitis,
Chronic hepatitis due to cryptosporidium infection,
Chronic lymphocytic meningitis,
Chronic mucocutaneous candidiasis,
Colitis,
Cutaneous anergy,
Decreased circulating antibody level,
Decreased circulating beta-2-microglobulin level,
Decreased lymphocyte proliferation in response to mitogen,
Decreased proportion of CD4-positive helper T cells,
Diarrhea,
Dysarthria,
Failure to thrive,
Gait ataxia,
Infectious encephalitis,
Lack of T cell function,
Malabsorption,
Neutropenia,
Neutropenia in presence of anti-neutropil antibodies,
Pancytopenia,
Panhypogammaglobulinemia,
Protracted diarrhea,
Recurrent Staphylococcus aureus infections,
Recurrent bacterial infections,
Recurrent candida infections,
Recurrent fungal infections,
Recurrent herpes,
Recurrent infection of the gastrointestinal tract,
Recurrent lower respiratory tract infections,
Recurrent protozoan infections,
Recurrent respiratory infections,
Recurrent upper respiratory tract infections,
Recurrent urinary tract infections,
Recurrent viral infections,
Reduced MHC II surface expression,
Rhinitis,
Sclerosing cholangitis,
Sinusitis,
Skin rash,
T lymphocytopenia,
Villous atrophy,
Viral hepatitis
[+]
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Mouse (9 sources):
abnormal B lymphocyte antigen presentation,
abnormal Kupffer cell morphology,
abnormal MHC II cell surface expression on macrophages,
abnormal dendritic cell morphology,
abnormal level of surface class II molecules,
abnormal thymus cortex morphology,
decreased CD4-positive, alpha beta T cell number,
decreased IgG1 level,
decreased single-positive T cell number
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View all ortholog results at Monarch
|
Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.