| Monarch Ortholog Phenotypes
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Human (35 sources):
Aminoaciduria,
Bone pain,
Bowing of the legs,
Bulging epiphyses,
Chronic kidney disease,
Delayed epiphyseal ossification,
Enlargement of the ankles,
Enlargement of the wrists,
Femoral bowing,
Fibular bowing,
Focal segmental glomerulosclerosis,
Glomerular sclerosis,
Glycosuria,
Hypercalciuria,
Hyperphosphaturia,
Hypophosphatemia,
Hypophosphatemic rickets,
Low-molecular-weight proteinuria,
Metaphyseal irregularity,
Microscopic hematuria,
Nephrocalcinosis,
Nephrolithiasis,
Osteomalacia,
Proximal tubulopathy,
Recurrent fractures,
Renal insufficiency,
Renal phosphate wasting,
Renal tubular atrophy,
Rickets,
Short stature,
Sparse bone trabeculae,
Thin bony cortex,
Tibial bowing,
Tubulointerstitial fibrosis,
obsolete Increased serum 1,25-dihydroxyvitamin D3
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Mouse (13 sources):
abnormal kidney corticomedullary boundary morphology,
abnormal renal protein reabsorption,
abnormal renal transport,
abnormal tooth development,
cellular phenotype,
decreased urine creatinine level,
decreased urine pH,
hydroxyprolinuria,
increased urine beta2-microglobulin level,
increased urine insulin level,
[+]
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View all ortholog results at Monarch
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Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.