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Summary Expression Phenotypes Gene Literature (9) GO Terms (2) Nucleotides (45) Proteins (27) Interactants (79) Wiki

gdf6     growth differentiation factor 6

Anatomical Phenotypes
Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.
decreased size of the eye (2 sources), increased apoptosis in neural progenitor cell (2 sources), abnormal development of pronephric kidney (1 source), abnormal eye morphology (1 source), abnormal pronephric kidney morphology (1 source), abnormal protein phosphorylation (1 source), abnormal retinal layer (1 source), absent amacrine cell (1 source), absent retinal ganglion cell (1 source), decreased cell population proliferation in eye (1 source), decreased size of the eye primordium (1 source), partially ventralized tadpole (1 source)
Expression Phenotypes
Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: gdf6 manipulated (5 sources)
Experiments (Reagents)
These are short form descriptions of experiments using reagents targeting the gene of interest.
Xla Wt + gdf6 MO (7 sources), Xla Wt + gdf6 (2 sources), Xla Wt + gdf6 MO (1 source), Xla Wt + gdf6 MO (1 source)
Monarch Ortholog Phenotypes
These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (65 sources): Abnormal cranial nerve morphology, Abnormal electroretinogram, Abnormal rib morphology, Abnormal sacrum morphology, Abnormal shoulder morphology, Abnormal temporal bone morphology, Abnormal vertebral segmentation and fusion, Abnormality of cardiovascular system morphology, Abnormality of limb bone morphology, Abnormality of neuronal migration, [+]
Mouse (17 sources): abnormal articular cartilage morphology, abnormal hearing physiology, abnormal incudomalleolar joint morphology, abnormal incudostapedial joint morphology, abnormal incus morphology, abnormal malleus morphology, abnormal middle ear ossicle morphology, abnormal stapes annular ligament morphology, abnormal tarsal bone morphology, absent coronal suture, [+]

View all ortholog results at Monarch