Cachexia, Colitis, Crusting erythematous dermatitis, Decreased circulating prealbumin concentration, Dependency on intravenous nutrition, Diabetes mellitus, Diarrhea, Eczematoid dermatitis, Elevated circulating hepatic transaminase concentration, Eosinophilia, Failure to thrive in infancy, Gastritis, Hepatitis, Hyperthyroidism, Hypoalbuminemia, Hypocalcemia, Hypomagnesemia, Hypothyroidism, Ileus, Immune dysregulation, Increased circulating IgE level, Inflammatory abnormality of the skin, Insulin receptor antibody positivity, Interstitial pneumonitis, Iron deficiency anemia, Lymphadenopathy, Malabsorption, Membranous nephropathy, Meningitis, Myositis, Nail dystrophy, Nasogastric tube feeding, Nephrotic syndrome, Neutropenia, Neutropenia in presence of anti-neutropil antibodies, Osteomyelitis, Pneumonia, Psoriasiform dermatitis, Recurrent gastroenteritis, Recurrent infections, Recurrent respiratory infections, Recurrent skin infections, Reduced proportion of CD4-negative, CD8-negative, alpha-beta regulatory T cells, Respiratory distress, Secretory diarrhea, Sepsis, Splenomegaly, Thrombocytopenia, Thyroiditis, Tubulointerstitial nephritis, Type I diabetes mellitus, Urticaria, Villous atrophy, Vomiting, obsolete Eczematoid dermatitis, obsolete Hypotrichosis

abnormal effector T cell morphology, abnormal gut-associated lymphoid tissue morphology, abnormal hepatic cord morphology, abnormal immune system organ morphology, abnormal intraepithelial T cell morphology, abnormal lymph node B cell domain morphology, abnormal lymph node T cell domain morphology, abnormal lymph node medullary cord morphology, abnormal lymphocyte physiology, abnormal megakaryocyte progenitor cell morphology, abnormal mesenteric lymph node morphology, abnormal pulmonary alveolus morphology, abnormal regulatory T cell morphology, abnormal regulatory T cell physiology, abnormal reproductive system development, abnormal respiratory mucosa goblet cell morphology, abnormal spleen B cell follicle morphology, abnormal spleen white pulp morphology, abnormal tail ring morphology, abnormal thymus cortex morphology, abnormal thymus morphology, absent prostate gland anterior lobe, absent regulatory T cells, absent seminal vesicle, absent spleen marginal zone, autoimmune response, crypts of Lieberkuhn abscesses, decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number, decreased body size, decreased double-positive T cell number, decreased erythrocyte cell number, decreased hematocrit, decreased hemoglobin content, decreased regulatory T cell number, decreased thymocyte number, delayed eyelid opening, dermatitis, dilated liver sinusoidal spaces, enlarged lymph nodes, epidermal hyperplasia, hemosiderosis, hunched posture, immune system phenotype, increased CD4-positive, alpha beta T cell number, increased CD8-positive, alpha-beta T cell number, increased IgG1 level, increased T cell apoptosis, increased T cell proliferation, increased activated T cell number, increased autoantibody level, increased circulating interferon-gamma level, increased circulating interleukin-10 level, increased circulating interleukin-4 level, increased circulating interleukin-5 level, increased circulating interleukin-6 level, increased circulating tumor necrosis factor level, increased dendritic cell number, increased regulatory T cell number, increased sensitivity to induced morbidity/mortality, increased spleen red pulp amount, increased spleen weight, increased spleen white pulp amount, increased susceptibility to autoimmune disorder, increased susceptibility to type IV hypersensitivity reaction, insulitis, intermingled spleen red and white pulp, lethality at weaning, complete penetrance, multifocal hepatic necrosis, no abnormal phenotype detected, pale kidney, pale liver, polychromatophilia, postnatal lethality, postnatal lethality, complete penetrance, premature death, respiratory system inflammation, salivary gland inflammation, scaly ears, short perineum, skin lesions, small thymus