pknox1 Phenotypes

Phenotypes

XB-GENEPAGE-6460201

Gene Symbol: pknox1 Gene Name: PBX/knotted 1 homeobox 1

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Computed annotations: pknox1 assayed (4 sources)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Mouse (37 sources): abnormal blood cell morphology/development, abnormal embryonic tissue morphology, abnormal erythropoiesis, abnormal extraembryonic tissue morphology, abnormal eye development, abnormal liver development, abnormal pluripotent precursor cell morphology, abnormal prenatal growth/weight/body size, abnormal retina neuronal layer morphology, abnormal retina pigment epithelium morphology, abnormal visceral endoderm morphology, absent anterior visceral endoderm, absent mesoderm, decreased IgG1 level, decreased angiogenesis, decreased birth body size, decreased embryo size, decreased fetal size, decreased hematocrit, decreased hemoglobin content, decreased mature B cell number, decreased mean corpuscular hemoglobin concentration, decreased percent body fat/body weight, decreased pre-B cell number, decreased single-positive T cell number, embryonic growth retardation, embryonic lethality between implantation and somite formation, complete penetrance, embryonic lethality, complete penetrance, failure of primitive streak formation, increased T cell apoptosis, increased double-negative T cell number, increased nucleated erythrocyte cell number, increased pro-B cell number, lethality throughout fetal growth and development, complete penetrance, no abnormal phenotype detected, perinatal lethality, complete penetrance, vision/eye phenotype [+]

Monarch Ortholog Phenotypes

These phenotypes are associated with this gene with a has phenotype relation via Monarch.

Mouse (37 sources): abnormal blood cell morphology/development, abnormal embryonic tissue morphology, abnormal erythropoiesis, abnormal extraembryonic tissue morphology, abnormal eye development, abnormal liver development, abnormal pluripotent precursor cell morphology, abnormal prenatal growth/weight/body size, abnormal retina neuronal layer morphology, abnormal retina pigment epithelium morphology, [+]