tyrobp Phenotypes

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Phenotypes

Gene Literature (1)

Nucleotides (63)

Interactants (44)

XB-GENEPAGE-6489425

Gene Symbol: tyrobp Gene Name: transmembrane immune signaling adaptor TYROBP

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Computed annotations: tyrobp assayed (2 sources)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (51 sources): Abnormal adipose tissue morphology, Abnormal epiphysis morphology, Abnormal foot morphology, Abnormality of movement, Abnormality of the hand, Abnormal speech pattern, Abnormal upper motor neuron morphology, Acute leukemia, Aggressive behavior, Apraxia, Arthralgia, Atypical behavior, Axonal loss, Babinski sign, Basal ganglia calcification, Bone cyst, Bone pain, Caudate atrophy, Cerebral atrophy, Cerebral calcification, Cerebral cortical atrophy, Chorea, Developmental regression, Disinhibition, Disturbed sensory perception, EEG abnormality, Euphoria, Frontal lobe dementia, Functional abnormality of the gastrointestinal tract, Gait disturbance, Gliosis, Hydrocephalus, Hypoplasia of the corpus callosum, Inappropriate behavior, Irritability, Lack of insight, Leukoencephalopathy, Limitation of joint mobility, Memory impairment, Myoclonus, Oculomotor apraxia, Pathologic fracture, Peripheral demyelination, Personality changes, Primitive reflex, Reduced bone mineral density, Seizure, Skeletal dysplasia, Spasticity, Urinary incontinence, Ventriculomegaly [+]
Mouse (49 sources): abnormal axon morphology, abnormal bone remodeling, abnormal decidua basalis morphology, abnormal dendritic cell physiology, abnormal excitatory postsynaptic currents, abnormal inhibitory postsynaptic currents, abnormal maternal decidual layer morphology, abnormal microglial cell morphology, abnormal myelopoiesis, abnormal NK T cell physiology, abnormal osteoclast differentiation, abnormal osteoclast morphology, abnormal osteoclast physiology, abnormal uterine spiral artery morphology, abnormal uterine spiral artery remodeling, behavior/neurological phenotype, decreased interferon-gamma secretion, decreased prepulse inhibition, decreased startle reflex, decreased susceptibility to experimental autoimmune encephalomyelitis, decreased susceptibility to induced arthritis, decreased susceptibility to type IV hypersensitivity reaction, decreased T cell proliferation, decreased uterine NK cell number, enhanced long term potentiation, failure of embryo implantation, immune system phenotype, impaired natural killer cell mediated cytotoxicity, increased anti-double stranded DNA antibody level, increased autoantibody level, increased B cell proliferation, increased bone mass, increased bone mineral content, increased bone trabecula number, increased dendritic cell number, increased germinal center B cell number, increased IgG2a level, increased IgG3 level, increased interleukin-6 secretion, increased natural killer cell mediated cytotoxicity, increased physiological sensitivity to xenobiotic, increased spleen germinal center number, increased spleen germinal center size, increased susceptibility to Herpesvirales infection, increased trabecular bone mass, increased trabecular bone volume, nervous system phenotype, reduced fertility, reduced sensorimotor gating [+]
View all ortholog results at Monarch