Arthralgia, Axonal loss, Babinski sign, Basal ganglia calcification, Behavioral abnormality, Bone cyst, Bone pain, Caudate atrophy, Cerebral atrophy, Cerebral calcification, Cerebral cortical atrophy, Chorea, Developmental regression, Disinhibition, EEG abnormality, Euphoria, Frontal lobe dementia, Functional abnormality of the gastrointestinal tract, Gait disturbance, Gliosis, Hydrocephalus, Hypoplasia of the corpus callosum, Inappropriate behavior, Irritability, Lack of insight, Leukoencephalopathy, Limitation of joint mobility, Memory impairment, Myoclonus, Neurological speech impairment, Oculomotor apraxia, Pathologic fracture, Peripheral demyelination, Personality changes, Primitive reflex, Reduced bone mineral density, Seizure, Skeletal dysplasia, Spasticity, Urinary incontinence, Ventriculomegaly

abnormal osteoclast differentiation, abnormal osteoclast morphology, abnormal osteoclast physiology, abnormal uterine spiral artery morphology, abnormal uterine spiral artery remodeling, behavior/neurological phenotype, decreased T cell proliferation, decreased interferon-gamma secretion, decreased prepulse inhibition, decreased startle reflex, decreased susceptibility to experimental autoimmune encephalomyelitis, decreased susceptibility to induced arthritis, decreased susceptibility to type IV hypersensitivity reaction, decreased uterine NK cell number, enhanced long term potentiation, failure of embryo implantation, immune system phenotype, impaired natural killer cell mediated cytotoxicity, increased B cell proliferation, increased IgG2a level, increased IgG3 level, increased anti-double stranded DNA antibody level, increased autoantibody level, increased bone mass, increased bone mineral content, increased bone trabecula number, increased dendritic cell number, increased germinal center B cell number, increased interleukin-6 secretion, increased natural killer cell mediated cytotoxicity, increased physiological sensitivity to xenobiotic, increased spleen germinal center number, increased spleen germinal center size, increased susceptibility to Herpesvirales infection, increased trabecular bone mass, increased trabecular bone volume, nervous system phenotype, reduced fertility, reduced sensorimotor gating