| Monarch Ortholog Phenotypes
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Human (28 sources):
Abdominal wall muscle weakness,
Arrhythmia,
Cardiomyocyte hypertrophy,
Cardiomyopathy,
Decreased muscle glycogen content,
Decreased muscle mass,
Difficulty walking,
Distal muscle weakness,
EMG: myopathic abnormalities,
Exertional dyspnea,
Foot dorsiflexor weakness,
Increased mitochondrial number,
Limb-girdle muscle weakness,
Muscle weakness,
Neck flexor weakness,
Palpitations,
Right bundle branch block,
ST segment elevation,
Shoulder girdle muscle weakness,
Skeletal muscle atrophy,
T-wave inversion,
Upper limb muscle weakness,
Ventricular arrhythmia,
Ventricular fibrillation,
Ventricular hypertrophy,
Ventricular septal hypertrophy,
Ventricular tachycardia,
Vertigo
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Mouse (15 sources):
abnormal cellular respiration,
abnormal embryo size,
abnormal glycogen homeostasis,
abnormal lipid oxidation,
abnormal muscle electrophysiology,
abnormal response to exercise,
decreased aerobic running capacity,
decreased carbon dioxide production,
decreased energy expenditure,
decreased oxygen consumption,
[+]
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View all ortholog results at Monarch
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Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.