egr2 Phenotypes

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Phenotypes

Gene Literature (273)

Nucleotides (77)

Interactants (1064)

XB-GENEPAGE-853289

Gene Symbol: egr2 Gene Name: early growth response 2 (Krox-20 homolog)

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: egr2 assayed (27 sources)
Computed annotations: egr2 assayed (8 sources)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (29 sources): Abnormal cranial nerve morphology, Areflexia, Decreased motor nerve conduction velocity, Decreased number of peripheral myelinated nerve fibers, Distal amyotrophy, Distal muscle weakness, Distal sensory impairment, Foot dorsiflexor weakness, Generalized hypotonia, Hammertoe, Hypertrophic nerve changes, Hyporeflexia, Hypotonia, Increased CSF protein, Kyphoscoliosis, Motor delay, Neonatal hypotonia, Nystagmus, Onion bulb formation, Peripheral hypomyelination, Peripheral neuropathy, Pes cavus, Respiratory insufficiency, Segmental peripheral demyelination/remyelination, Sensory ataxia, Split hand, Steppage gait, Ulnar claw, Upper limb muscle weakness [+]
Mouse (46 sources): abnormal Schwann cell morphology, abnormal abducens nerve morphology, abnormal aortic valve morphology, abnormal bone mineralization, abnormal cochlear ganglion morphology, abnormal cranial ganglia morphology, abnormal geniculate ganglion morphology, abnormal glossopharyngeal ganglion morphology, abnormal hindbrain development, abnormal long bone epiphyseal plate morphology, abnormal mandible morphology, abnormal motor capabilities/coordination/movement, abnormal neuromuscular synapse morphology, abnormal rhombomere morphology, abnormal sciatic nerve morphology, abnormal skeleton development, abnormal trigeminal ganglion morphology, abnormal vagus ganglion morphology, abnormal vagus nerve morphology, absent rhombomere 3, absent rhombomere 5, decreased body size, decreased diameter of femur, decreased diameter of radius, decreased diameter of tibia, decreased locomotor activity, decreased rhombomere 3 size, decreased rhombomere 5 size, decreased rhombomere 6 size, decreased width of hypertrophic chondrocyte zone, delayed eyelid opening, enlarged aortic valve, fusion of glossopharyngeal and vagus nerve, hindlimb paralysis, impaired limb coordination, increased Schwann cell proliferation, increased pulmonary respiratory rate, integument phenotype, lethality at weaning, complete penetrance, neonatal lethality, incomplete penetrance, postnatal lethality, complete penetrance, postnatal lethality, incomplete penetrance, short radius, thick aortic valve cusps, thick pulmonary valve cusps, weakness [+]
View all ortholog results at Monarch