Failure to thrive secondary to recurrent infections, Fever, Hepatitis, Hepatosplenomegaly, Immunodeficiency, Increased circulating antibody level, Lymphopenia, Otitis media, Pneumonia, Protracted diarrhea, Recurrent abscess formation, Recurrent candida infections, Recurrent herpes, Recurrent infections, Recurrent pneumonia, T lymphocytopenia

abnormal double-negative T cell morphology, abnormal excitatory postsynaptic potential, abnormal gamma-delta T cell differentiation, abnormal intraepithelial T cell morphology, abnormal lateral geniculate nucleus morphology, abnormal long term depression, abnormal regulatory T cell physiology, abnormal single-positive T cell number, abnormal superior colliculus morphology, abnormal thymocyte activation, absent gamma-delta intraepithelial T cell, absent long term depression, decreased CD4-positive, alpha beta T cell number, decreased NK T cell number, decreased T cell proliferation, decreased double-positive T cell number, decreased single-positive T cell number, decreased splenocyte proliferation, decreased thymocyte apoptosis, decreased thymocyte number, enhanced long term potentiation, enlarged lateral ventricles, enlarged lymph nodes, enlarged thymus cortex, immune system phenotype, increased double-negative T cell number, increased interferon-gamma secretion, increased natural killer cell mediated cytotoxicity, increased regulatory T cell number, increased susceptibility to experimental autoimmune encephalomyelitis, no abnormal phenotype detected, postnatal lethality, complete penetrance, reduced long term depression, small thymus, small thymus medulla