trem2 Phenotypes

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Phenotypes

Gene Literature (2)

Nucleotides (54)

Interactants (100)

XB-GENEPAGE-922280

Gene Symbol: trem2 Gene Name: triggering receptor expressed on myeloid cells 2

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Computed annotations: trem2 assayed (2 sources)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (51 sources): Abnormal adipose tissue morphology, Abnormal epiphysis morphology, Abnormal foot morphology, Abnormality of movement, Abnormality of the hand, Abnormal speech pattern, Abnormal upper motor neuron morphology, Acute leukemia, Aggressive behavior, Apraxia, Arthralgia, Atypical behavior, Axonal loss, Babinski sign, Basal ganglia calcification, Bone cyst, Bone pain, Caudate atrophy, Cerebral atrophy, Cerebral calcification, Cerebral cortical atrophy, Chorea, Developmental regression, Disinhibition, Disturbed sensory perception, EEG abnormality, Euphoria, Frontal lobe dementia, Functional abnormality of the gastrointestinal tract, Gait disturbance, Gliosis, Hydrocephalus, Hypoplasia of the corpus callosum, Inappropriate behavior, Irritability, Lack of insight, Leukoencephalopathy, Limitation of joint mobility, Memory impairment, Myoclonus, Oculomotor apraxia, Pathologic fracture, Peripheral demyelination, Personality changes, Primitive reflex, Reduced bone mineral density, Seizure, Skeletal dysplasia, Spasticity, Urinary incontinence, Ventriculomegaly [+]
Mouse (15 sources): abnormal blood volume, abnormal cell cycle checkpoint function, abnormal glial cell apoptosis, abnormal interferon level, abnormal interleukin level, abnormal microglial cell physiology, abnormal tumor necrosis factor level, decreased macrophage cell number, decreased macrophage proliferation, decreased microglial cell activation, impaired macrophage phagocytosis, increased circulating interleukin-6 level, increased circulating tumor necrosis factor level, increased macrophage apoptosis, increased susceptibility to endotoxin shock [+]
View all ortholog results at Monarch