Monarch Ortholog Phenotypes
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Mouse (30 sources):
abnormal developmental patterning,
abnormal ectoderm development,
abnormal embryonic tissue morphology,
abnormal extraembryonic tissue morphology,
abnormal hair follicle melanocyte morphology,
abnormal hair follicle morphology,
abnormal hair follicle orientation,
abnormal primitive streak morphology,
absent proamniotic cavity,
arrested T cell differentiation,
darkened coat color,
decreased DN1 thymic pro-T cell number,
decreased DN2 thymocyte number,
decreased DN3 thymocyte number,
decreased cell proliferation,
decreased curvature of zigzag hairs,
decreased double-negative T cell number,
decreased embryo size,
decreased gamma-delta T cell number,
decreased thymocyte number,
decreased zigzag hair amount,
embryonic growth retardation,
embryonic lethality between somite formation and embryo turning, complete penetrance,
failure to gastrulate,
focal dorsal hair loss,
immune system phenotype,
increased T cell apoptosis,
increased apoptosis,
increased keratinocyte proliferation,
rough coat
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