| Monarch Ortholog Phenotypes
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Human (16 sources):
Areflexia,
Axonal degeneration,
Broad-based gait,
Decreased muscle mass,
Decreased number of peripheral myelinated nerve fibers,
Delayed ability to walk,
Generalized hypotonia,
Inability to walk,
Knee flexion contracture,
Muscle weakness,
[+]
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Mouse (8 sources):
abnormal axon morphology,
abnormal cerebellum deep nucleus morphology,
decreased Purkinje cell number,
decreased retina ganglion cell number,
decreased retina inner nuclear layer thickness,
increased exploration in new environment,
retina ganglion cell degeneration,
thin retina outer plexiform layer
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View all ortholog results at Monarch
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Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.