| Monarch Ortholog Phenotypes
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Human (22 sources):
Abnormal bleeding,
Abnormality of the menstrual cycle,
Abnormality of thrombocytes,
Absence of alpha granules,
Acute leukemia,
Bruising susceptibility,
Decreased mean platelet volume,
Ecchymosis,
Epistaxis,
Gastrointestinal hemorrhage,
Impaired collagen-induced platelet aggregation,
Impaired thrombin-induced platelet aggregation,
Menorrhagia,
Myelodysplasia,
Myelofibrosis,
Petechiae,
Prolonged bleeding time,
Reduced prothrombin consumption,
Reduced quantity of Von Willebrand factor,
Reduced von Willebrand factor activity,
Splenomegaly,
Thrombocytopenia
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Mouse (20 sources):
abnormal blood cell morphology/development,
abnormal bone marrow cell morphology/development,
abnormal embryonic erythrocyte morphology,
abnormal embryonic erythropoiesis,
abnormal erythropoiesis,
abnormal hematopoietic stem cell physiology,
abnormal megakaryocyte differentiation,
abnormal megakaryocyte progenitor cell morphology,
absent erythrocytes,
absent erythroid progenitor cell,
absent platelets,
decreased erythrocyte cell number,
decreased hemoglobin content,
hematopoietic system phenotype,
increased hematopoietic stem cell number,
increased splenocyte number,
lethality throughout fetal growth and development, complete penetrance,
postnatal lethality, complete penetrance,
prenatal lethality,
preweaning lethality, complete penetrance
[+]
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View all ortholog results at Monarch
|
Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.