Monarch Ortholog Phenotypes
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Mouse (30 sources):
abnormal embryo size,
abnormal embryo turning,
abnormal epidermal-dermal junction morphology,
abnormal forebrain development,
abnormal glomerular capillary morphology,
abnormal hindbrain development,
abnormal midbrain development,
abnormal osteoclast differentiation,
abnormal osteoclast morphology,
abnormal skeleton development,
abnormal skeleton physiology,
decreased bone strength,
decreased osteoblast cell number,
decreased osteoclast cell number,
dermatitis,
embryonic lethality prior to tooth bud stage,
increased anti-histone antibody level,
increased circulating interleukin-6 level,
increased interleukin-6 secretion,
increased mesangial cell number,
increased plasma cell number,
increased renal glomerulus basement membrane thickness,
increased renal glomerulus lobularity,
increased susceptibility to systemic lupus erythematosus,
podocyte foot process effacement,
premature death,
preweaning lethality, complete penetrance,
renal glomerular immunoglobulin deposits,
small kidney,
thick skin
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