| Monarch Ortholog Phenotypes
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Human (6 sources):
Diffuse mesangial sclerosis,
Focal segmental glomerulosclerosis,
Nephrotic syndrome,
Proteinuria,
Seizure,
Sensorineural hearing impairment
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Mouse (24 sources):
abnormal embryo size,
abnormal embryo turning,
abnormal glomerular capillary morphology,
abnormal mitochondrial physiology,
abnormal podocyte morphology,
abnormal podocyte slit junction morphology,
abnormal tail bud morphology,
abnormal vitreous body morphology,
decreased podocyte number,
dilated renal tubules,
disheveled coat,
embryonic lethality prior to tooth bud stage,
embryonic lethality, complete penetrance,
hunched posture,
increased mitochondrial size,
increased renal glomerulus basement membrane thickness,
moribund,
pale kidney,
persistence of hyaloid vascular system,
podocyte foot process effacement,
premature death,
preweaning lethality, complete penetrance,
renal cast,
small kidney
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View all ortholog results at Monarch
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Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.