Monarch Ortholog Phenotypes
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Human (21 sources):
Abnormality of skin morphology,
Abnormality of the nervous system,
Absent speech,
Behavioral abnormality,
Chorea,
Developmental regression,
Dyskinesia,
Dystonia,
EEG abnormality,
Epileptic encephalopathy,
Generalized hypotonia,
Global developmental delay,
Hypotonia,
Hypsarrhythmia,
Infantile spasms,
Intellectual disability,
Microcephaly,
Myoclonus,
Myopia,
Seizure,
Spasticity
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Mouse (49 sources):
abnormal AMPA-mediated synaptic currents,
abnormal CNS synaptic transmission,
abnormal NMDA-mediated synaptic currents,
abnormal associative learning,
abnormal cued conditioning behavior,
abnormal dendrite morphology,
abnormal dendritic spine morphology,
abnormal discrimination learning,
abnormal excitatory postsynaptic currents,
abnormal excitatory postsynaptic potential,
abnormal learning/memory/conditioning,
abnormal long term depression,
abnormal long term object recognition memory,
abnormal miniature excitatory postsynaptic currents,
abnormal object recognition memory,
abnormal operant conditioning behavior,
abnormal social investigation,
abnormal spatial learning,
abnormal spatial reference memory,
abnormal spatial working memory,
abnormal suckling behavior,
abnormal synapse morphology,
abnormal temporal memory,
absence of NMDA-mediated synaptic currents,
absent gastric milk in neonates,
absent long term depression,
absent suckling reflex,
behavior/neurological phenotype,
decreased anxiety-related response,
decreased body size,
decreased physiological sensitivity to xenobiotic,
disorganized barrel cortex,
enhanced contextual conditioning behavior,
enhanced cued conditioning behavior,
enhanced long term potentiation,
fast extinction of fear memory,
impaired swimming,
impaired synaptic plasticity,
increased prepulse inhibition,
increased startle reflex,
increased thigmotaxis,
neonatal lethality, complete penetrance,
nervous system phenotype,
perinatal lethality, complete penetrance,
postnatal lethality, complete penetrance,
preweaning lethality, incomplete penetrance,
reduced long term depression,
reduced long term potentiation,
social withdrawal
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View all ortholog results at Monarch
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