ada Phenotypes

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Phenotypes

Gene Literature (23)

Nucleotides (185)

Interactants (12)

XB-GENEPAGE-950500

Gene Symbol: ada Gene Name: adenosine deaminase

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Computed annotations: ada assayed (5 sources)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (68 sources): Abnormal lymphocyte morphology, Abnormality of humoral immunity, Abnormality of pelvic girdle bone morphology, Abnormality of the metaphysis, Absence of lymph node germinal center, Absent specific antibody response, Absent tonsils, Allergy, Anemia, Anterior rib cupping, Anti-thyroid peroxidase antibody positivity, Aplasia of the thymus, Aplasia/Hypoplasia of the eyebrow, Asthma, Autoimmune hemolytic anemia, Autoimmune thrombocytopenia, Autoimmunity, B lymphocytopenia, B-cell lymphoma, Chronic diarrhea, Decreased circulating IgA level, Decreased circulating IgG2 level, Decreased circulating total IgM, Desquamation of skin soon after birth, Diarrhea, Diffuse mesangial sclerosis, Dry skin, Edema, Eosinophilia, Erythroderma, Failure to thrive, Fever, Growth arrest lines, Hepatomegaly, Hypoplasia of the thymus, Hypoproteinemia, Hypothyroidism, Increased circulating IgE level, Inflammatory abnormality of the skin, Lack of T cell function, Leukocytosis, Lymphadenopathy, Lymphoma, Lymphopenia, Nephrotic syndrome, Platyspondyly, Pneumonia, Pruritus, Pulmonary insufficiency, Recurrent bacterial infections, Recurrent fungal infections, Recurrent opportunistic infections, Recurrent otitis media, Recurrent pneumonia, Recurrent upper respiratory tract infections, Recurrent viral infections, Reduced red cell adenosine deaminase level, Sepsis, Severe B lymphocytopenia, Severe combined immunodeficiency, Short toe, Sinusitis, Splenomegaly, T lymphocytopenia, Thickened skin, Thrombocytopenia, Thyroiditis, obsolete Hypotrichosis [+]
Mouse (41 sources): abnormal costochondral joint morphology, abnormal dendritic cell physiology, abnormal enzyme/coenzyme level, abnormal hepatocyte morphology, abnormal lung vasculature morphology, abnormal nucleotide metabolism, abnormal penile erection, abnormal placenta morphology, abnormal placenta vasculature, abnormal pulmonary alveolar system morphology, abnormal pulmonary alveolus morphology, abnormal pulmonary gas exchange, abnormal renal glomerulus morphology, abnormal renal tubule morphology, abnormal spleen red pulp morphology, abnormal thymus corticomedullary boundary morphology, abnormal vascular smooth muscle physiology, cardiovascular system phenotype, decreased double-positive T cell number, decreased hepatocyte number, decreased lung compliance, decreased placenta weight, embryo phenotype, increased airway resistance, increased dendritic cell number, increased double-negative T cell number, increased granulocyte number, increased hepatocyte karyomegaly, increased lung elastance, increased macrophage cell number, increased right ventricle systolic pressure, maternal effect, neonatal lethality, complete penetrance, neonatal lethality, incomplete penetrance, no abnormal phenotype detected, postnatal lethality, complete penetrance, renal/urinary system phenotype, small liver, small spleen, small thymus, vascular smooth muscle hypertrophy [+]
View all ortholog results at Monarch